A Trimodal Ultrasound, Photoacoustic and Magnetic Resonance Imaging Approach for Longitudinal Post-operative Monitoring of Stem Cells in the Spinal Cord.
A Trimodal Ultrasound, Photoacoustic and Magnetic Resonance Imaging Approach for Longitudinal Post-operative Monitoring of Stem Cells in the Spinal Cord.
复制标题
脊髓中干细胞纵向监测的三峰超声，光声和磁共振成像方法。
DOI：
10.1016/j.ultrasmedbio.2020.08.026
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发表时间：
2020-12
影响因子：
2.9
通讯作者：
Emelianov SY
中科院分区：
文献类型：
--
作者：
Kubelick KP;Emelianov SY
Longitudinal monitoring of stem cells in the spinal cord could unveil critical information needed to understand regenerative processes, thereby expediting therapy development and translation. We introduce a post-operative trimodal imaging approach to monitor stem cells in the spinal cord over time. A key aspect of the approach is to label the stem cells with Prussian blue nanocubes (PBNCs), which simultaneously possess optical and magnetic properties for ultrasound-guided photoacoustic (US/PA) and magnetic resonance imaging (MRI) contrast. PBNC-Labeled stem cells were injected into the spinal cord of immunodeficient rats and tracked with US/PA imaging and MRI up to 14 d post-injection. Good agreement was observed between imaging modalities in vivo. Our results suggest that further development of the US/PA/MR imaging approach may create a powerful tool to aid development of regenerative therapies of the spinal cord, and the non-invasive imaging approach can ultimately be deployed in intra- and post-operative environments.
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影响因子：
3.5
作者：
Provost J;Papadacci C;Arango JE;Imbault M;Fink M;Gennisson JL;Tanter M;Pernot M
通讯作者：
Pernot M
影响因子：
38.1
作者：
Boulis, Nicholas M.;Federici, Thais;Feldman, Eva L.
通讯作者：
Feldman, Eva L.
影响因子：
4.8
作者：
Okada, S;Ishii, K;Okano, H
通讯作者：
Okano, H
影响因子：
1.7
作者：
Lamanna, Jason J.;Urquia, Lindsey N.;Boulis, Nicholas M.
通讯作者：
Boulis, Nicholas M.
影响因子：
5.3
作者：
Kubelick, Kelsey P.;Emelianov, Stanislav Y.
通讯作者：
Emelianov, Stanislav Y.