Mesothelial to mesenchyme transition as a major developmental and pathological player in trunk organs and their cavities.
Mesothelial to mesenchyme transition as a major developmental and pathological player in trunk organs and their cavities.
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DOI：
10.1038/s42003-018-0180-x
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发表时间：
2018
影响因子：
5.9
通讯作者：
Rinkevich Y
中科院分区：
文献类型：
--
作者：
Koopmans T;Rinkevich Y
埋在腔中的内部器官由称为间皮的上皮单层衬里。间皮细胞越来越多地参与驱动各种内部器官病理，因为在间皮细胞中起作用的许多正常胚胎发育途径，例如调节上皮-间质转化的那些，也驱动成年生活中的疾病进展。在这里，我们总结了不同动物模型和器官系统的观察结果，这些观察结果共同指向上皮向间充质转化在驱动组织纤维化、急性瘢痕形成和癌症转移中的核心作用。因此，靶向间皮素转化途径的药物可能对患有这些疾病的患者具有广泛的治疗益处。Tim Koopmans和Yuval Rinkevich回顾了最近的发现，这些发现将间皮瘤的胚胎程序与成人病理学（如纤维化，急性瘢痕形成和癌症转移）联系起来，这些胚胎程序驱动上皮细胞向间充质细胞转化。他们强调了药物开发的新途径，这些药物将靶向间皮细胞间质转化的途径。
The internal organs embedded in the cavities are lined by an epithelial monolayer termed the mesothelium. The mesothelium is increasingly implicated in driving various internal organ pathologies, as many of the normal embryonic developmental pathways acting in mesothelial cells, such as those regulating epithelial-to-mesenchymal transition, also drive disease progression in adult life. Here, we summarize observations from different animal models and organ systems that collectively point toward a central role of epithelial-to-mesenchymal transition in driving tissue fibrosis, acute scarring, and cancer metastasis. Thus, drugs targeting pathways of mesothelium’s transition may have broad therapeutic benefits in patients suffering from these diseases. Tim Koopmans and Yuval Rinkevich review recent findings linking the mesothelium’s embryonic programs that drive epithelial-to-mesenchyme transition with adult pathologies, such as fibrosis, acute scarring, and cancer metastasis. They highlight new avenues for drug development that would target pathways of the mesothelium’s mesenchymal transition.
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DOI：
10.1046/j.1525-1438.1995.05040306.x
发表时间：
1995-07-01
影响因子：
4.8
作者：
BELLER, U;HAIMOVITCH, R;BENSASSON, S
通讯作者：
BENSASSON, S
影响因子：
2.7
作者：
Bohnenpoll, Tobias;Bettenhausen, Eva;Kispert, Andreas
通讯作者：
Kispert, Andreas
DOI：
10.1016/j.jss.2009.10.033
发表时间：
2010-12
期刊：
The Journal of surgical research
影响因子：
--
作者：
Berg T;DeLanghe S;Al Alam D;Utley S;Estrada J;Wang KS
通讯作者：
Wang KS
DOI：
10.1084/jem.20011794
发表时间：
2002-12-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bellingan GJ;Xu P;Cooksley H;Cauldwell H;Shock A;Bottoms S;Haslett C;Mutsaers SE;Laurent GJ
通讯作者：
Laurent GJ
影响因子：
13.5
作者：
Asahina, Kinji;Tsai, Shirley Y.;Li, Peng;Ishii, Mamoru;Maxson, Robert E., Jr.;Sucov, Henry M.;Tsukamoto, Hidekau
通讯作者：
Tsukamoto, Hidekau