Development of connectivity in a motoneuronal network in Drosophila larvae.
Development of connectivity in a motoneuronal network in Drosophila larvae.
复制标题
DOI：
10.1016/j.cub.2014.12.056
复制
发表时间：
2015-03-02
期刊：
影响因子：
9.2
通讯作者：
Landgraf, Matthias
中科院分区：
文献类型：
--
作者：
Couton, Louise;Mauss, Alex S.;Yunusov, Temur;Diegelmann, Soeren;Evers, Jan Felix;Landgraf, Matthias
我们对神经网络如何发展的理解大多是基于对感觉系统的研究，揭示了通常高度刻板的连接模式，特别是当这些连接从感觉神经元的突触前末梢分叉时。我们对运动神经网络的连接策略知之甚少，而运动神经网络的连接则集中在运动神经元的树突上。在这里，我们研究了识别的运动神经元与感觉神经元和中间神经元之间的突触连接的模式，在运动网络的果蝇幼虫，以及这些变化，因为它的发展。我们发现，随着动物的成长，运动神经元与现有突触前伙伴的突触数量增加。不同的运动神经元形成特征性的细胞类型特异性连接模式。同时，运动神经元树突上形成的突触数量存在相当大的变化，这与感觉神经元突触前末梢的刻板报道形成对比。当两个相同细胞类型的运动神经元接触一个共同的中间神经元伴侣时，每个突触后细胞可以达到不同的连接结果。实验改变运动神经元树突的定位表明，树突乔木突触前合作伙伴终端的地理是一个重要的决定因素，在塑造模式的连接。在果蝇幼虫的运动网络中，识别出的神经元之间形成的连接集合表现出意想不到的可变性。突触的数量和形成连接的可能性似乎是由一个细胞一个细胞的基础上，主要由运动神经元末梢的突触后树突。生长的运动神经元巩固突触与现有的突触前伙伴运动神经元树突状乔木是积极的缔约方在设置连接模式细胞类型的特定功能共存的变化在个别细胞水平运动神经元布线策略可能与感觉神经元的神经连接的发展主要是在感觉网络的背景下研究。Couton等人探索在运动网络中，突触连接如何在发育过程中发生变化，发现连接模式在细胞之间显示出相当大的变化，运动神经元树突在塑造这些方面发挥着积极作用。
Much of our understanding of how neural networks develop is based on studies of sensory systems, revealing often highly stereotyped patterns of connections, particularly as these diverge from the presynaptic terminals of sensory neurons. We know considerably less about the wiring strategies of motor networks, where connections converge onto the dendrites of motoneurons. Here, we investigated patterns of synaptic connections between identified motoneurons with sensory neurons and interneurons in the motor network of the Drosophila larva and how these change as it develops. We find that as animals grow, motoneurons increase the number of synapses with existing presynaptic partners. Different motoneurons form characteristic cell-type-specific patterns of connections. At the same time, there is considerable variability in the number of synapses formed on motoneuron dendrites, which contrasts with the stereotypy reported for presynaptic terminals of sensory neurons. Where two motoneurons of the same cell type contact a common interneuron partner, each postsynaptic cell can arrive at a different connectivity outcome. Experimentally changing the positioning of motoneuron dendrites shows that the geography of dendritic arbors in relation to presynaptic partner terminals is an important determinant in shaping patterns of connectivity. In the Drosophila larval motor network, the sets of connections that form between identified neurons manifest an unexpected level of variability. Synapse number and the likelihood of forming connections appear to be regulated on a cell-by-cell basis, determined primarily by the postsynaptic dendrites of motoneuron terminals. Growing motoneurons consolidate synapses with existing presynaptic partners Motoneuron dendritic arbors are active parties in setting connectivity patterns Cell-type-specific features coexist with variations at the individual cell level Motoneuron wiring strategies may contrast with those of sensory neurons The development of neural connections has mainly been studied in the context of sensory networks. Couton et al. explore how, in a motor network, synaptic connections change during development, finding that connectivity patterns show considerable variability between cells and that motoneuron dendrites play an active role in shaping these.
登录
查看更多内容
影响因子：
16.2
作者：
Ashrafi S;Betley JN;Comer JD;Brenner-Morton S;Bar V;Shimoda Y;Watanabe K;Peles E;Jessell TM;Kaltschmidt JA
通讯作者：
Kaltschmidt JA
影响因子：
16.2
作者：
Gordon, Michael D.;Scott, Kristin
通讯作者：
Scott, Kristin
影响因子：
9.2
作者：
Hiesinger, P. Robin;Zhai, R. Grace;Bellen, Hugo J.
通讯作者：
Bellen, Hugo J.
影响因子：
25
作者：
Chou, Ya-Hui;Spletter, Maria L.;Yaksi, Emre;Leong, Jonathan C. S.;Wilson, Rachel I.;Luo, Liqun
通讯作者：
Luo, Liqun
影响因子：
16.2
作者：
Aberle, H;Haghighi, AP;Goodman, CS
通讯作者：
Goodman, CS