Effects of ibogaine, and cocaine and morphine after ibogaine, on ventral tegmental dopamine neurons.
Effects of ibogaine, and cocaine and morphine after ibogaine, on ventral tegmental dopamine neurons.
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伊博加因以及伊博加因后的可卡因和吗啡对腹侧被盖多巴胺神经元的影响。
DOI：
10.1016/0024-3205(96)00412-2
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发表时间：
1996
期刊：
影响因子：
6.1
通讯作者：
Ali,SF
中科院分区：
文献类型：
--
作者：
French,ED;Dillon,K;Ali,SF
伊博加因是一种含有生物碱的吲哚，已被证明可以降低自我给药方案中吗啡和可卡因的注射率。由于吗啡和可卡因诱导的多巴胺释放调节是冲动依赖性的，并且对于其增强作用至关重要，因此伊博加因对多巴胺神经元活动的破坏可以解释其所谓的“抗成瘾”特性。因此，本研究旨在确定：（1）伊博加因对 VTA 多巴胺神经元活性的急性影响，以及（2）伊博加因预处理是否会导致多巴胺神经元对吗啡和可卡因反应的持续改变。麻醉动物的细胞外记录发现，静脉注射伊博加因可显着刺激 VTA 多巴胺神经元放电。然而，伊博加因预处理（6-8小时和19小时前）未能改变VTA神经元的自发活动，或这些多巴胺神经元对吗啡或可卡因的反应。因此，伊博加因对 VTA 神经元的兴奋作用并不持久，也不会持续改变可卡因或吗啡引起的多巴胺神经元冲动活动的变化。因此，必须探索其他机制来解释伊博加因的抗成瘾特性。
Ibogaine, an indole containing alkaloid, has been shown to reduce the rate of injection of morphine and cocaine in self-administration protocols. Since morphine- and cocaine-induced modulation of dopamine release is impulse dependent and essential for their reinforcing effects, disruption of dopamine neuronal activity by ibogaine could explain its purported ‘antiaddictive’ properties. Therefore, the present study was designed to determine: (1) the acute effects of ibogaine on the activity of VTA dopamine neurons, and (2) whether ibogaine pretreatment causes a persistent modification of the dopamine neuronal response to morphine and cocaine. Extracellular recordings in anesthetized animals found that intravenous ibogaine markedly excited VTA dopamine neuronal firing. However, ibogaine pretreatment (6–8 hr and 19 hr before) failed to alter either the spontaneous activity of VTA neurons, or the response of these dopamine neurons to morphine or cocaine. Thus, ibogaine's excitatory effect on VTA neurons is not longlasting nor does it persistently alter cocaine- or morphine-induced changes in dopamine neuron impulse activity. Therefore, other mechanisms must be explored to account for the proposed antiaddictive properties of ibogaine.
影响因子：
5
作者：
GLICK, SD;ROSSMAN, K;CARLSON, JN
通讯作者：
CARLSON, JN