Multimodal image analysis of clinical influences on preterm brain development.
Multimodal image analysis of clinical influences on preterm brain development.
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DOI：
10.1002/ana.24995
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发表时间：
2017-08
影响因子：
11.2
通讯作者：
Edwards AD
中科院分区：
文献类型：
--
作者：
Ball G;Aljabar P;Nongena P;Kennea N;Gonzalez-Cinca N;Falconer S;Chew ATM;Harper N;Wurie J;Rutherford MA;Counsell SJ;Edwards AD
早产与许多复杂的白色和灰质异常以及长期神经认知障碍的高发生率相关。缺乏对这些异常及其与临床事件相关性的综合了解。本研究的目的是确定特定模式的异常大脑发育及其产前和产后的前因。在449名婴儿（226名男性）的前瞻性队列中，我们结合多种成像模式进行了多变量和数据驱动分析。使用典型相关分析，我们寻找与特定临床和环境因素相关的可分离的多模态成像标记物，并与2年时的神经发育结局相关。我们发现了五种独立的神经解剖变异模式，这些变异与临床因素有关，包括年龄、早产、性别、宫内并发症和产后逆境。我们还证实了神经解剖学异常的影像学标记物与2年时认知和运动结果不良之间的相关性。这种数据驱动的方法定义了脑发育不良的新的和临床相关的成像标志物，为早产儿脑损伤的性质提供了新的见解。神经学年鉴2017;82：233-246
Premature birth is associated with numerous complex abnormalities of white and gray matter and a high incidence of long‐term neurocognitive impairment. An integrated understanding of these abnormalities and their association with clinical events is lacking. The aim of this study was to identify specific patterns of abnormal cerebral development and their antenatal and postnatal antecedents. In a prospective cohort of 449 infants (226 male), we performed a multivariate and data‐driven analysis combining multiple imaging modalities. Using canonical correlation analysis, we sought separable multimodal imaging markers associated with specific clinical and environmental factors and correlated to neurodevelopmental outcome at 2 years. We found five independent patterns of neuroanatomical variation that related to clinical factors including age, prematurity, sex, intrauterine complications, and postnatal adversity. We also confirmed the association between imaging markers of neuroanatomical abnormality and poor cognitive and motor outcomes at 2 years. This data‐driven approach defined novel and clinically relevant imaging markers of cerebral maldevelopment, which offer new insights into the nature of preterm brain injury. Ann Neurol 2017;82:233–246
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影响因子：
8
作者：
Delobel-Ayoub, Malika;Arnaud, Catherine;Larroque, Beatrice
通讯作者：
Larroque, Beatrice
影响因子：
5.1
作者：
Maalouf, EF;Duggan, PJ;Edwards, AD
通讯作者：
Edwards, AD
影响因子：
3.7
作者：
Dubois, J.;Benders, M.;Hueppi, P. S.
通讯作者：
Hueppi, P. S.
影响因子：
5.7
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Groves, Adrian R.;Smith, Stephen M.;Westlye, Lars T.
通讯作者：
Westlye, Lars T.
影响因子：
8
作者：
Inder, TE;Warfield, SK;Volpe, JJ
通讯作者：
Volpe, JJ