The tumor microenvironment.
The tumor microenvironment.
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DOI：
10.1016/j.cub.2020.06.081
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发表时间：
2020-08-17
期刊：
影响因子：
--
通讯作者：
Simon MC
中科院分区：
文献类型：
--
作者：
Anderson NM;Simon MC
肿瘤不仅仅是一组癌细胞，而是浸润性和驻留性宿主细胞、分泌因子和细胞外基质的异质集合。肿瘤细胞在其宿主组织内刺激显著的分子、细胞和物理变化，以支持肿瘤的生长和进展。新兴的肿瘤微环境是一个复杂且不断演变的实体。肿瘤微环境的组成因肿瘤类型而异，但其标志性特征包括免疫细胞、基质细胞、血管和细胞外基质。人们认为“肿瘤微环境不只是一个沉默的旁观者，而是癌症进展的积极促进者”（Truffi et al., 2020）。在肿瘤生长的早期，癌细胞和肿瘤微环境的组成部分之间形成了一种动态的互惠关系，这种关系支持癌细胞的生存、局部侵袭和转移传播。为了克服缺氧和酸性微环境，肿瘤微环境协调了一个促进血管生成的程序，以恢复氧气和营养供应，并清除代谢废物。肿瘤被多种适应性和先天免疫细胞浸润，这些细胞可以发挥致瘤和抗致瘤功能（图1）。越来越多关于肿瘤微环境的文献已经确定了治疗干预的新靶点。
A tumor is not simply a group of cancer cells, but rather a heterogeneous collection of infiltrating and resident host cells, secreted factors and extracellular matrix. Tumor cells stimulate significant molecular, cellular and physical changes within their host tissues to support tumor growth and progression. An emerging tumor microenvironment is a complex and continuously evolving entity. The composition of the tumor microenvironment varies between tumor types, but hallmark features include immune cells, stromal cells, blood vessels, and extracellular matrix. It is believed that the "tumor microenvironment is not just a silent bystander, but rather an active promoter of cancer progression" (Truffi et al., 2020). Early in tumor growth, a dynamic and reciprocal relationship develops between cancer cells and components of the tumor microenvironment that supports cancer cell survival, local invasion and metastatic dissemination. To overcome a hypoxic and acidic microenvironment, the tumor microenvironment coordinates a program that promotes angiogenesis to restore oxygen and nutrient supply and remove metabolic waste. Tumors become infiltrated with diverse adaptive and innate immune cells that can perform both pro- and anti- tumorigenic functions (Figure 1). An expanding literature on the tumor microenvironment has identified new targets within it for therapeutic intervention.
DOI：
10.1007/978-3-030-37184-5_6
发表时间：
2020-01-01
期刊：
TUMOR MICROENVIRONMENT: NON-HEMATOPOIETIC CELLS
影响因子：
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作者：
Sobierajska, Katarzyna;Ciszewski, Wojciech Michal;Niewiarowska, Jolanta
通讯作者：
Niewiarowska, Jolanta