Thalamic medial dorsal nucleus atrophy in medial temporal lobe epilepsy: A VBM meta-analysis.
Thalamic medial dorsal nucleus atrophy in medial temporal lobe epilepsy: A VBM meta-analysis.
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DOI：
10.1016/j.nicl.2012.11.004
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发表时间：
2012
影响因子：
4.2
通讯作者：
Fox, Peter T.
中科院分区：
文献类型：
--
作者：
Barron, Daniel S.;Fox, P. Mickle;Laird, Angela R.;Robinson, Jennifer L.;Fox, Peter T.
内侧颞叶癫痫（MTLE）与海马内外的MTLE网络病理学相关。本荟萃分析的目的是确定一致的MTLE结构变化，以指导这些领域的后续目标分析。我们进行了解剖似然估计（ALE）荟萃分析22全脑体素为基础的形态学实验，从11个已发表的研究。我们把这些实验分成三组。然后，我们构建了一个荟萃分析连接模型（MACM）的一致的MTLE结构变化的ALE分析报告的地区。ALE仅在致痫性海马和双侧丘脑中报告了VBM研究中空间一致的结构变化;在丘脑内，丘脑内侧背核（MDN丘脑）代表最大的会聚（多重比较校正后P < 0.05）。随后的海马和同侧MDN丘脑的MACM表明，海马和同侧MDN丘脑功能共激活，是同一网络内的节点，这表明MDN丘脑损伤可能是由MTLE网络兴奋性毒性引起的。尽管我们的研究样本量很大，但这些发现比以前的报告更具限制性，并证明了我们的纳入过滤器和最近修改的荟萃分析方法在近似临床相关性方面的实用性。在动物和人类研究中经常观察到丘脑病理学，这表明它可能是临床上有用的指标。丘脑特异性研究作为临床标志物有待进一步研究。方法：对11篇关于内侧颞叶癫痫（MTLE）的病理学研究进行Meta分析。双侧丘脑是最一致的海马外病理。在丘脑内，内侧背核（MDN）是最重要的。我们建议MDN丘脑作为MTLE未来研究的靶点。我们推荐这些改进的方法用于未来的VBM荟萃分析。
Medial temporal lobe epilepsy (MTLE) is associated with MTLE network pathology within and beyond the hippocampus. The purpose of this meta-analysis was to identify consistent MTLE structural change to guide subsequent targeted analyses of these areas. We performed an anatomic likelihood estimation (ALE) meta-analysis of 22 whole-brain voxel-based morphometry experiments from 11 published studies. We grouped these experiments in three ways. We then constructed a meta-analytic connectivity model (MACM) for regions of consistent MTLE structural change as reported by the ALE analysis. ALE reported spatially consistent structural change across VBM studies only in the epileptogenic hippocampus and the bilateral thalamus; within the thalamus, the medial dorsal nucleus of the thalamus (MDN thalamus) represented the greatest convergence (P < 0.05 corrected for multiple comparisons). The subsequent MACM for the hippocampus and ipsilateral MDN thalamus demonstrated that the hippocampus and ipsilateral MDN thalamus functionally co-activate and are nodes within the same network, suggesting that MDN thalamic damage could result from MTLE network excitotoxicity. Notwithstanding our large sample of studies, these findings are more restrictive than previous reports and demonstrate the utility of our inclusion filters and of recently modified meta-analytic methods in approximating clinical relevance. Thalamic pathology is commonly observed in animal and human studies, suggesting it could be a clinically useful indicator. Thalamus-specific research as a clinical marker awaits further investigation. ► Meta-analyzed 11 studies of pathology in medial temporal lobe epilepsy (MTLE). ► The bilateral thalamus is the most consistent extra-hippocampal pathology. ► Within the thalamus, the medial dorsal nucleus (MDN) was the most significant. ► We suggest the MDN thalamus as a target for future studies in MTLE. ► We recommend these modified methods for future VBM meta-analyses.
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影响因子：
4.8
作者：
Eickhoff, Simon B.;Laird, Angela R.;Grefkes, Christian;Wang, Ling E.;Zilles, Karl;Fox, Peter T.
通讯作者：
Fox, Peter T.
影响因子：
5.7
作者：
Bernasconi, N;Duchesne, S;Bernasconi, A
通讯作者：
Bernasconi, A
影响因子：
14.5
作者：
Guye, Maxime;Regis, Jean;Bartolomei, Fabrice
通讯作者：
Bartolomei, Fabrice
影响因子：
5.6
作者：
Fisher, Robert;Salanova, Vicenta;Graves, Nina
通讯作者：
Graves, Nina
DOI：
10.1523/jneurosci.4004-09.2009
发表时间：
2009-11-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Laird AR;Eickhoff SB;Li K;Robin DA;Glahn DC;Fox PT
通讯作者：
Fox PT