Brain-State-Dependent Modulation of Neuronal Firing and Membrane Potential Dynamics in the Somatosensory Thalamus during Natural Sleep.
Brain-State-Dependent Modulation of Neuronal Firing and Membrane Potential Dynamics in the Somatosensory Thalamus during Natural Sleep.
复制标题
自然睡眠期间体感丘脑神经元放电和膜电位动态的大脑状态依赖性调节。
DOI：
10.1016/j.celrep.2019.01.038
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发表时间：
2019
期刊：
影响因子：
8.8
通讯作者：
L. Gentet
中科院分区：
文献类型：
--
作者：
N. Urbain;Nicolas Fourcaud;Samuel Laheux;Paul Antoine Salin;L. Gentet
丘脑在哺乳动物大脑的睡眠节律中起着中心作用，然而，令人惊讶的是，人们对它的功能以及在NREM睡眠(NREM)期间与局部皮质振荡的相互作用知之甚少。我们研究了自然NREM过程中丘脑腹侧后内侧核(VPM)和后内侧核(POM)两个对应核团皮质桶活动的神经元相关性。我们的数据揭示了(1)VPM和POM活动在整个NREM发作中的明显调制，(2)丘脑核对皮质慢波和纺锤波的特异性相位锁定，(3)VPM神经元中仅与皮质纺锤体部分重叠的细胞特异性阈值下纺锤体振荡，以及(4)纺锤体特征在整个NREM发作中演变，并根据NREM后的状态而变化。综上所述，我们的结果表明，在自然睡眠中，桶状皮质在慢节奏的产生和传递到躯体感觉丘脑中起主导作用，并反过来对纺锤波起主导作用。
The thalamus plays a central role in sleep rhythms in the mammalian brain and, yet, surprisingly little is known about its function and interaction with local cortical oscillations during NREM sleep (NREM). We investigated the neuronal correlates of cortical barrel activity in the two corresponding thalamic nuclei, the ventral posterior medial (VPM), and the posterior medial (Pom) nuclei during natural NREM in mice. Our data reveal (1) distinct modulations of VPM and Pom activity throughout NREM episodes, (2) a thalamic nucleus-specific phase-locking to cortical slow and spindle waves, (3) cell-specific subthreshold spindle oscillations in VPM neurons that only partially overlap with cortical spindles, and (4) that spindle features evolve throughout NREM episodes and vary according to the post-NREM state. Taken together, our results suggest that, during natural sleep, the barrel cortex exerts a leading role in the generation and transfer of slow rhythms to the somatosensory thalamus and reciprocally for spindle oscillations.
影响因子：
2.5
作者：
Viaene, Angela N.;Petrof, Iraklis;Sherman, S. Murray
通讯作者：
Sherman, S. Murray
影响因子：
2.5
作者：
LU, SM;GUIDO, W;SHERMAN, SM
通讯作者：
SHERMAN, SM