Temporal analysis of intratumoral metabolic heterogeneity characterized by textural features in cervical cancer.
Temporal analysis of intratumoral metabolic heterogeneity characterized by textural features in cervical cancer.
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DOI：
10.1007/s00259-012-2332-4
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发表时间：
2013-05
影响因子：
9.1
通讯作者：
Grigsby, Perry W.
中科院分区：
文献类型：
--
作者：
Yang, Fei;Thomas, Maria A.;Dehdashti, Farrokh;Grigsby, Perry W.
本初步研究的目的是探讨接受放化疗的宫颈癌患者肿瘤内[18 F]氟脱氧葡萄糖（FDG）蓄积异质性的时间行为。本研究纳入了20例接受联合放化疗的国际妇产科联合会Ib 1至IVa期宫颈癌患者。患者在治疗前、治疗期间第2周和第4周以及治疗完成后第12周接受FDG-PET/CT检查。根据对治疗的反应对患者进行分类，包括完全代谢反应者（CMR）、部分代谢反应者（PMR）和出现新发疾病的残留疾病患者（NEW）。根据治疗后是否存在残留原发性肿瘤，将患者分为CMR和PMR/NEW 2组。评估了以区域尺度纹理特征为特征的肿瘤内FDG异质性的时间分布，并与区分反应组背景下的标准化摄取值（SUV）指数（SUVmax和SUVmean）进行了比较。区域尺度上的纹理特征，重点是表征肿瘤内高摄取的连续区域，随时间变化显著（P < 0.001），并进一步表现出负的时间趋势的患者CMR，而描述连续低摄取区域的特征沿着测量肿瘤内连续等信号区域的不均匀性的特征在PMR/NEW患者中表现出显著的时间变化，（P < 0.03），但没有显示出随时间的持续趋势。两组患者的SUV指数在病程中均显示出显著变化CMR组SUVmax、SUVmean P < 0.001; PMR/NEW患者的SUVmax和SUVmean分别为P = 0.0109和0.0136），此外，在CMR患者中表现出恒定的下降时间趋势，而时间曲线的特征是下降趋势，治疗第四周后，PMR/NEW患者的倾向性增加。结果表明，肿瘤内FDG分布异质性的时间演变特点，在区域尺度上使用基于图像的纹理特征，可以提供一个替代或替代的选择，了解肿瘤的反应，放化疗治疗和解释FDG积累动态的恶性宫颈肿瘤患者在疾病过程中。
Aim of this pilot study was to explore temporal behaviors of intratumoral [18F] fluorodeoxyglucose (FDG) accumulation heterogeneity at a regional scale in patients with cervical cancer undergoing chemoradiotherapy. Twenty patients with International Federation of Gynecology and Obstetrics stages Ib1 to IVa cervical cancer treated with combined chemoradiotherapy were included in this study. Patients underwent FDG-PET/CT before treatment, at weeks 2 and 4 during treatment, and at 12 weeks after completion of therapy. Patients were classified based on response to therapy including complete metabolic responders (CMR), partial metabolic responders (PMR), and patients with residual disease who developed new disease (NEW). Based on the presence of residual primary tumor following therapy, patients were divided into 2 groups, CMR and PMR/NEW. Temporal profiles of intratumoral FDG heterogeneity characterized by texture features at a regional scale were assessed and compared with those of the standardized uptake values (SUV) indices (SUVmax and SUVmean) within the context of differentiating response groups. Texture features at a regional scale with emphasis on characterizing contiguous regions of high uptake within tumors varied significantly over time (Ps < 0.001) and further exhibited negative temporal trends in patients of CMR, while features describing contiguous regions of low uptake along with those measuring the non-uniformity of contiguous isointense regions within tumors exhibited significant temporal changes in patients of PMR/NEW (Ps < 0.03) but showed no persistent trends against time. Both SUV indices showed significant changes during the course of disease for either patient group (Ps < 0.001 for SUVmax and SUVmean in patients of CMR; P = 0.0109 and 0.0136 respectively for SUVmax and SUVmean in patients of PMR/NEW) and, moreover, demonstrated a constant descending temporal tendency in patients of CMR while a temporal profile characterized with a declining tendency up to the fourth week into treatment followed afterwards by a rising inclination in patients of PMR/NEW. Results suggest that temporal evolutions of intratumoral FDG distribution heterogeneity characterized at a regional scale using image based texture features may provide an adjunctive or alternative option for understanding tumor response to chemoradiotherapy treatment and interpreting FDG accumulation dynamics in patients with malignant cervical tumors during the course of disease.
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影响因子：
3.3
作者：
Yang, Fei;Grigsby, Perry W.
通讯作者：
Grigsby, Perry W.
DOI：
10.1016/s0360-3016(02)02705-0
发表时间：
2002-06-01
影响因子：
7
作者：
Miller, TR;Grigsby, PW
通讯作者：
Grigsby, PW
影响因子：
5.7
作者：
van Stiphout, Ruud G. P. M.;Lammering, Guido;Lambin, Philippe
通讯作者：
Lambin, Philippe
影响因子：
9.3
作者：
Dehdashti, Farrokh;Grigsby, Perry W.;Welch, Michael J.
通讯作者：
Welch, Michael J.
DOI：
10.2967/jnumed.108.053397
发表时间：
2008-12
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Eary JF;O'Sullivan F;O'Sullivan J;Conrad EU
通讯作者：
Conrad EU