Microbiotas from UC patients display altered metabolism and reduced ability of LAB to colonize mucus.
Microbiotas from UC patients display altered metabolism and reduced ability of LAB to colonize mucus.
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DOI：
10.1038/srep01110
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发表时间：
2013
影响因子：
4.6
通讯作者：
Licht, Tine Rask
中科院分区：
文献类型：
--
作者：
Vigsnaes, Louise Kristine;van den Abbeele, Pieter;Sulek, Karolina;Frandsen, Henrik Lauritz;Steenholdt, Casper;Brynskov, Jorn;Vermeiren, Joan;van de Wiele, Tom;Licht, Tine Rask
我们比较了来自缓解期（n = 4）或复发期（n = 4）的溃疡性结肠炎（UC）患者或来自健康受试者（n = 4）的粪便微生物群落。这些社区用于接种的动态体外肠道模型，其中包含集成的粘蛋白覆盖的微观世界。我们发现“粘液”的微生物群与“内腔”的微生物群有很大不同。这部分是由于产生乳酸的细菌群体（LAB）的粘液相关群体减少，因为与源自健康受试者的那些相比，源自UC患者的LAB具有显著降低的定殖粘蛋白覆盖的微观世界的能力。我们发现复发和缓解期UC患者的代谢组之间存在显著差异，而缓解期患者的代谢组与健康受试者相似。这些新的发现对理解UC的复杂病因学做出了重要贡献。
We compared fecal microbial communities derived either from Ulcerative Colitis (UC) patients in remission (n = 4) or in relapse (n = 4), or from healthy subjects (n = 4). These communities were used for inoculation of a dynamic in vitro gut model, which contained integrated mucin-covered microcosms. We found that the microbiota of the ‘mucus’ largely differed from that of the ‘lumen’. This was partly due to decreased mucus-associated populations of lactic acid producing bacterial populations (LAB), as LAB originating from UC patients had a significantly decreased capacity to colonize the mucin-covered microcosms as compared to those originating from healthy subjects. We found significant differences between the metabolomes of UC patients in relapse and remission, respectively, while the metabolome of patients in remission resembled that of healthy subjects. These novel findings constitute an important contribution to the understanding of the complex etiology of UC.
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影响因子：
2.1
作者：
Bergstrom, Anders;Licht, Tine R.;Bahl, Martin I.
通讯作者：
Bahl, Martin I.
影响因子：
6.3
作者：
Hengstermann, Susanne;Valentini, Luzia;Lochs, Herbert
通讯作者：
Lochs, Herbert
DOI：
10.1073/pnas.0908876106
发表时间：
2009-10-06
影响因子：
11.1
作者：
Kankainen, Matti;Paulin, Lars;de Vos, Willem M.
通讯作者：
de Vos, Willem M.
影响因子：
4.9
作者：
Hanauer, SB
通讯作者：
Hanauer, SB
影响因子：
4.4
作者：
Lee, Ju-Hoon;Li, Xiulan;O'Sullivan, Daniel J.
通讯作者：
O'Sullivan, Daniel J.