Superthreshold behavior and threshold estimates of ultrasound-induced lung hemorrhage in adult rats: role of beamwidth.
Superthreshold behavior and threshold estimates of ultrasound-induced lung hemorrhage in adult rats: role of beamwidth.
复制标题
成年大鼠超声诱导肺出血的超阈值行为和阈值估计：波束宽度的作用。
DOI：
10.1109/58.971723
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Zachary,JF
中科院分区：
文献类型：
--
作者：
O'BrienJr,WD;Simpson,DG;Frizzell,LA;Zachary,JF
It is well documented that ultrasound-induced lung hemorrhage can occur in mice, rats, rabbits, pigs, and monkeys. The objective of this study was to assess the role of the ultrasound beamwidth (beam diameter incident on the lung surface) on lesion threshold and size. A total of 144 rats were randomly exposed to pulsed ultrasound at three exposure levels and four beamwidths (12 rats per group). The three in situ peak rarefactional pressures were about 5, 7.5, and 10 MPa. The four 19-mm-diameter focused transducers had measured pulse-echo -6-dB focal beamwidths of 470 /spl mu/m (2.8 MHz; f/1), 930 /spl mu/m (2.8 MHz; f/2), 310 /spl mu/m (5.6 MHz; f/1), and 510 /spl mu/m (5.6 MHz; f/2). Exposure durations were 10 s, pulse repetition frequencies were 1 kHz, and pulse durations were 1.3 /spl mu/s (2.8 MHz; f/1), 1.2 /spl mu/s (2.8 MHz; f/2), 0.8 /spl mu/s (5.6 MHz; f/1) and 1.1 /spl mu/s (5.6 MHz; f/2). The lesion surface area and depth were measured for each rat as well as the percentage of rats with lesions per group. Logistic regression analysis and Gaussian-Tobit analysis methods were used to analyze the data. The effects of in situ peak rarefactional pressure and beamwidth were highly significant, but ultrasonic frequency was not significant. In addition, the estimated interaction between in situ peak rarefactional pressure and beamwidth was positive and highly significant. The ultrasound beamwidth incident on the lung surface was shown to strongly affect the percentage and size of ultrasound-induced lung hemorrhage lesions. Even though ultrasonic frequency was an experimental variable, it was not shown to affect the lesion percentage or size.
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钙增强氧自由基损伤肾线粒体的机制。
DOI：
--
发表时间：
1986
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Malis,CD;Bonventre,JV
通讯作者：
Bonventre,JV
DOI：
10.1016/s0021-9258(17)43600-3
发表时间：
1984-01
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
M. C. Beatrice;D. L. Stiers;D. Pfeiffer
通讯作者：
M. C. Beatrice;D. L. Stiers;D. Pfeiffer
维生素 E 可以防止化学引起的细胞损伤。
影响因子：
3.9
作者：
G. Pascoe;Donald J. Reed
通讯作者：
Donald J. Reed
抑制脂质过氧化而不预防离体大鼠肝细胞的细胞损伤。
影响因子：
3.8
作者：
Stacey,NH;Klaassen,CD
通讯作者：
Klaassen,CD
影响因子：
56.9
作者：
JEWELL, SA;BELLOMO, G;SMITH, MT
通讯作者：
SMITH, MT