Sex differences in depression: An immunological perspective.
Sex differences in depression: An immunological perspective.
复制标题
抑郁症的性别差异：免疫学角度。
DOI：
10.1016/j.brainresbull.2023.02.016
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发表时间：
2023-05
影响因子：
3.8
通讯作者：
中科院分区：
文献类型：
--
作者：
抑郁症是一种异质性疾病，其症状在个体之间存在差异。在一部分人中，抑郁症与免疫系统的改变有关，免疫系统的改变可能导致疾病的发作和病理学改变。与男性相比，女性患抑郁症的可能性是男性的两倍，平均而言，女性具有更敏感的适应性和先天免疫系统。模式识别受体（PRR）、损伤相关分子模式（DAMP）释放、细胞群和循环细胞因子的性别差异在炎症发作中起关键作用。先天免疫和适应性免疫的性别差异改变了对体内危险病原体或分子造成的损伤的反应和修复。本文综述了性别特异性免疫反应的证据，有助于抑郁症症状的性别差异，这可能是女性抑郁症发病率较高的原因。
Depression is a heterogenous disorder with symptoms that present differently across individuals. In a subset of people depression is associated with alterations of the immune system that may contribute to disorder onset and symptomology. Women are twice as likely to develop depression and on average have a more sensitive adaptive and innate immune system when compared to men. Sex differences in pattern recognition receptors (PRRs), release of damage-associated molecular patterns (DAMPs), cell populations, and circulating cytokines play a critical role in inflammation onset. Sex differences in innate and adaptive immunity change the response of and repair to damage caused by dangerous pathogens or molecules in the body. This article reviews the evidence for sex specific immune responses that contribute to the sex differences in symptoms of depression that may account for the higher rate of depression in women.
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影响因子：
4.3
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通讯作者：
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