Treatment resistance of rheumatoid arthritis relates to infection of periodontal pathogenic bacteria: a case-control cross-sectional study.
Treatment resistance of rheumatoid arthritis relates to infection of periodontal pathogenic bacteria: a case-control cross-sectional study.
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DOI：
10.1038/s41598-022-16279-z
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发表时间：
2022-07-19
影响因子：
4.6
通讯作者：
Takashiba, Shogo
中科院分区：
文献类型：
--
作者：
Takeuchi-Hatanaka, Kazu;Koyama, Yoshinobu;Okamoto, Kentaro;Sakaida, Kyosuke;Yamamoto, Tadashi;Takashiba, Shogo
最近的研究表明，牙周炎与类风湿性关节炎（RA）有关，牙周细菌，如放线菌聚集杆菌（Aa）和牙龈卟啉单胞菌（Pg）通过瓜氨酸蛋白参与RA的发病机制。吸烟也被证明与 RA 的发病机制有关。然而，人们对这种参与的程度仍知之甚少。此外，RA 和风湿性多肌痛 (PMR) 有时很难区分；然而，PMR与吸烟和牙周细菌因素之间的关系尚不清楚。本研究的目的是阐明 RA 或 PMR 患者牙周病原菌感染与吸烟之间的关系。这项病例对照研究包括 142 名未经治疗的 RA 或 PMR 患者。本研究评估了针对牙周致病菌抗原和抗瓜氨酸肽抗体（ACPA）的血清抗体滴度。在 RA 患者中，还研究了抗体滴度与 RA 疾病活动度以及治疗 3 个月后反应之间的关系。此外，还评估了吸烟的影响。尽管ACPA阳性RA组和ACPA阴性PMR组的血清牙周病原菌抗体滴度没有显着差异，但我们发现针对Pg的抗体滴度升高与ACPA值程度之间存在关联，特别是在阴性组和高值阳性组（≥100 U/mL）之间。针对 Aa 和 Pg 的抗体滴度没有随基线疾病活动评分 28 (DAS28) 的变化而变化；然而，根据 3 个月后的 DAS28 判断，抗体滴度高的患者 RA 治疗反应较差。我们找不到吸烟与这些参数之间的任何关联。牙周病原菌，尤其是 Pg，与 ACPA 水平升高有关。我们的研究结果表明，Pg 和 Aa 感染会干扰 RA 的治疗反应。
Recent studies have shown that periodontitis is associated with rheumatoid arthritis (RA) and periodontal bacteria, such as Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) are involved in the pathogenesis of RA via citrullinated proteins. Smoking has also been shown to be involved in the pathogenesis of RA; however, the extent of this involvement is still poorly understood. In addition, RA and polymyalgia rheumatica (PMR) are sometimes difficult to differentiate; however, the relationship between PMR and the factors from smoking and periodontal bacteria is unclear. The aim of this study was to clarify the relationship between periodontal pathogenic bacterial infections and smoking in patients with RA or PMR. This case–control study included 142 patients with untreated RA or PMR. This study evaluated the serum antibody titers against periodontal pathogenic bacterial antigens and an anti-citrullinated peptide antibody (ACPA). In patients with RA, the relationship between antibody titers and disease activity of RA and response after 3 months of treatment was also investigated. Additionally, the effects of smoking were evaluated. Although there was no significant difference in serum antibody titer against periodontal pathogenic bacteria between the ACPA-positive RA group and the ACPA-negative PMR group, we found an association between the elevated antibody titer against Pg and the degree of ACPA value, especially between negative group and high-value positive group (≥ 100 U/mL). The antibody titers against Aa and Pg did not differ depending on disease activity score 28 (DAS28) at baseline; however, patients with high antibody titers had poor RA therapeutic response as judged by DAS28 after 3 months. We could not find any association between smoking and any of these parameters. Periodontal pathogenic bacteria, especially Pg, are associated with elevated ACPA levels. Our findings suggest that Pg and Aa infections interfere with the therapeutic response of RA.
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影响因子：
4.9
作者：
Arvikar SL;Collier DS;Fisher MC;Unizony S;Cohen GL;McHugh G;Kawai T;Strle K;Steere AC
通讯作者：
Steere AC
影响因子：
3.7
作者：
Kobayashi T;Ito S;Kobayashi D;Shimada A;Narita I;Murasawa A;Nakazono K;Yoshie H
通讯作者：
Yoshie H
影响因子：
2.9
作者：
Kakuta E;Nomura Y;Morozumi T;Nakagawa T;Nakamura T;Noguchi K;Yoshimura A;Hara Y;Fujise O;Nishimura F;Kono T;Umeda M;Fukuda M;Noguchi T;Yoshinari N;Fukaya C;Sekino S;Numabe Y;Sugano N;Ito K;Kobayashi H;Izumi Y;Takai H;Ogata Y;Takano S;Minabe M;Makino-Oi A;Saito A;Abe Y;Sato S;Suzuki F;Takahashi K;Sugaya T;Kawanami M;Hanada N;Takashiba S;Yoshie H
通讯作者：
Yoshie H
影响因子：
13.8
作者：
Mankia, Kulveer;Cheng, Zijian;Emery, Paul
通讯作者：
Emery, Paul
影响因子：
7.3
作者：
Fuggle NR;Smith TO;Kaul A;Sofat N
通讯作者：
Sofat N