Distinct roles of methamphetamine in modulating spatial memory consolidation, retrieval, reconsolidation and the accompanying changes of ERK and CREB activation in hippocampus and prefrontal cortex.
Distinct roles of methamphetamine in modulating spatial memory consolidation, retrieval, reconsolidation and the accompanying changes of ERK and CREB activation in hippocampus and prefrontal cortex.
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DOI：
10.1016/j.neuropharm.2012.10.020
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发表时间：
2013-04
影响因子：
4.7
通讯作者：
Chen T
中科院分区：
文献类型：
--
作者：
Cao G;Zhu J;Zhong Q;Shi C;Dang Y;Han W;Liu X;Xu M;Chen T
滥用药物调节了人类的学习和记忆，但其潜在机制尚不清楚。细胞外信号调节蛋白(ERK)和转录因子cAMP反应元件结合蛋白(CREB)参与了与学习记忆相关的神经可塑性改变。在目前的研究中，我们使用Morris水迷宫来检测甲基苯丙胺对小鼠不同空间记忆过程的影响。然后，我们研究了ERK和CREB在海马区和前额叶皮质(PFC)的表达情况。我们发现，在最后一次学习试验后立即注射1.0 mg/kg的冰毒有助于巩固空间记忆。相反，在测试前30分钟注射相同剂量的冰毒对空间记忆提取没有影响。此外，提取后即刻注射冰毒1.0 mg/kg对空间记忆再巩固无影响。在记忆巩固后，发现海马区ERK和CREB都被激活，但在提取或重新巩固后，冰毒处理组小鼠没有发现。相反，在接受冰毒处理的小鼠中，在记忆提取后，发现了PFC中ERK和CREB的激活，但没有发现其他过程。这些结果表明，冰毒促进了空间记忆的巩固，而不是提取或再巩固。此外，海马区ERK和CREB信号通路的激活可能参与冰毒诱导的空间记忆改变。
Drugs of abuse modulated learning and memory in humans yet the underlying mechanism remained unclear. The extracellular signal-regulated kinase (ERK) and the transcription factor cAMP response element-binding protein (CREB) were involved in neuroplastic changes associated with learning and memory. In the current study, we used a Morris water maze to examine the effect of methamphetamine (METH) on different processes of spatial memory in mice. We then investigated the status of ERK and CREB in the hippocampus and prefrontal cortex (PFC). We found that 1.0 mg/kg dose of METH facilitated spatial memory consolidation when it was injected immediately after the last learning trial. In contrast, the same dose of METH had no effect on spatial memory retrieval when it was injected 30 min before the test. Furthermore, 1.0 mg/kg dose of METH injected immediately after retrieval had no effect on spatial memory reconsolidation. Activation of both ERK and CREB in the hippocampus was found following memory consolidation but not after retrieval or reconsolidation in METH-treated mouse groups. In contrast, activation of both ERK and CREB in the PFC was found following memory retrieval but not other processes in METH-treated mouse groups. These results suggested that METH facilitated spatial memory consolidation but not retrieval or reconsolidation. Moreover, activation of the ERK and CREB signaling pathway in the hippocampus might be involved in METH-induced spatial memory changes.
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影响因子：
3.5
作者：
Iniguez, Sergio D.;Charntikov, Sergios;Baella, Shelley A.;Herbert, Matthew S.;Bolanos-Guzman, Carlos A.;Crawford, Cynthia A.
通讯作者：
Crawford, Cynthia A.
影响因子：
7.6
作者：
Belcher, Annabelle M.;Feinstein, Erin M.;Marshall, John F.
通讯作者：
Marshall, John F.
DOI：
10.1124/jpet.106.114108
发表时间：
2007-02-01
影响因子：
3.5
作者：
Ito, Yukio;Takuma, Kazuhiro;Yamada, Kiyofumi
通讯作者：
Yamada, Kiyofumi
影响因子：
2.7
作者：
Brown, RW;Bardo, MT;Kraemer, PJ
通讯作者：
Kraemer, PJ
影响因子：
2.8
作者：
Kennedy, Colin D.;Houmes, Stephen W.;Sorg, Barbara A.
通讯作者：
Sorg, Barbara A.