Television watching and risk of colorectal adenoma.
Television watching and risk of colorectal adenoma.
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DOI：
10.1038/bjc.2014.655
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发表时间：
2015-03-03
影响因子：
8.8
通讯作者：
Giovannucci, E. L.
中科院分区：
文献类型：
--
作者：
Cao, Y.;Keum, N. N.;Chan, A. T.;Fuchs, C. S.;Wu, K.;Giovannucci, E. L.
长时间看电视是一种主要的久坐行为，与肥胖和糖尿病风险增加有关，并可能与结直肠癌的发生有关。我们在1988年至2008年期间对31名 065名接受⩾1内窥镜检查的男性进行了横断面分析，以评估坐着看电视及其与休闲体育活动对结直肠腺瘤风险的影响。用Logistic回归计算优势比(OR)和95%可信区间(CI)。长时间坐着看电视与结直肠腺瘤风险增加显著相关(n=4280)，调整体力活动或潜在的介体体重指数不会改变估计。每周看电视(0-6，7-13，14-20，21+ h)的OR值(95%CI)分别为1.00(参照值)、1.09(1.01-1.17)、1.16(1.06-1.27)和1.10(0.97-1.25)(OR值分别为1.11；95%CI：1.04-1.18；P趋势=0.001)。与最少久坐(每周看电视0-6 h)和最多运动(最高五分之一)的男性相比，最久坐(每周14+ h)和最不活跃(最低五分之一)的男性患腺瘤的风险显著增加(OR=1.2 5；95%CI：1.0 5-1.4 9)，尤其是对于高危腺瘤。长时间看电视与结直肠腺瘤风险的适度增加有关，独立于休闲时间的体力活动，并受肥胖的影响最小。
Prolonged TV watching, a major sedentary behaviour, is associated with increased risk of obesity and diabetes and may involve in colorectal carcinogenesis. We conducted a cross-sectional analysis among 31 065 men with ⩾1 endoscopy in the Health Professionals Follow-up Study (1988–2008) to evaluate sitting while watching TV and its joint influence with leisure-time physical activity on risk of colorectal adenoma. Logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Prolonged sitting while watching TV was significantly associated with increased risk of colorectal adenoma (n=4280), and adjusting for physical activity or a potential mediator body mass index did not change the estimates. The ORs (95% CIs) across categories of TV watching (0–6, 7–13, 14–20, and 21+ h per week) were 1.00 (referent), 1.09 (1.01–1.17), 1.16 (1.06–1.27), and 1.10 (0.97–1.25) (OR per 14-h per week increment=1.11; 95% CI: 1.04–1.18; Ptrend=0.001). Compared with the least sedentary (0–6 h per week of TV) and most physically active (highest quintile) men, the most sedentary (14+ h per week) and least active (lowest quintile) men had a significant increased risk of adenoma (OR=1.25; 95% CI: 1.05–1.49), particularly for high-risk adenoma. Prolonged TV viewing is associated with modest increased risk of colorectal adenoma independent of leisure-time physical activity and minimally mediated by obesity.
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