Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in heart failure patients.
Systemic oxidative stress is associated with lower aerobic capacity and impaired skeletal muscle energy metabolism in heart failure patients.
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DOI：
10.1038/s41598-021-81736-0
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发表时间：
2021-01-26
影响因子：
4.6
通讯作者：
Tsutsui H
中科院分区：
文献类型：
--
作者：
Yokota T;Kinugawa S;Hirabayashi K;Yamato M;Takada S;Suga T;Nakano I;Fukushima A;Matsushima S;Okita K;Tsutsui H
氧化应激在慢性心力衰竭（CHF）的进展中起作用。我们研究了系统性氧化应激是否与慢性心力衰竭患者的运动不耐受和骨骼肌异常有关。我们招募了30名男性：17名CHF患者，13名健康对照。所有参与者都进行了血液测试、心肺运动测试和磁共振波谱（MRS）。血清硫代巴比妥酸活性物质（TBARS，脂质过氧化物）显著高于对照组（5.1±1.1 vs. 3.4±0.7 μmol/L, p < 0.01），血清抗氧化剂超氧化物歧化酶（SOD）活性显著低于对照组（9.2±7.1 vs. 29.4±9.7单位/L， p < 0.01）。CHF患者在运动高峰和无氧阈值时的摄氧量（VO2）均显著降低；有氧能力参数与血清TBARS呈负相关，与血清SOD活性呈正相关。足底弯曲运动时的磷酸肌酸损失和参与者腿部肌肉的细胞内脂质含量分别由31磷-和1质子- mrs测量，在CHF患者中显著升高，表明肌肉内能量代谢异常。值得注意的是，骨骼肌异常与全身氧化应激增强有关。我们的分析显示，全身氧化应激与CHF患者全身有氧能力降低和骨骼肌功能障碍有关。
Oxidative stress plays a role in the progression of chronic heart failure (CHF). We investigated whether systemic oxidative stress is linked to exercise intolerance and skeletal muscle abnormalities in patients with CHF. We recruited 30 males: 17 CHF patients, 13 healthy controls. All participants underwent blood testing, cardiopulmonary exercise testing, and magnetic resonance spectroscopy (MRS). The serum thiobarbituric acid reactive substances (TBARS; lipid peroxides) were significantly higher (5.1 ± 1.1 vs. 3.4 ± 0.7 μmol/L, p < 0.01) and the serum activities of superoxide dismutase (SOD), an antioxidant, were significantly lower (9.2 ± 7.1 vs. 29.4 ± 9.7 units/L, p < 0.01) in the CHF cohort versus the controls. The oxygen uptake (VO2) at both peak exercise and anaerobic threshold was significantly depressed in the CHF patients; the parameters of aerobic capacity were inversely correlated with serum TBARS and positively correlated with serum SOD activity. The phosphocreatine loss during plantar-flexion exercise and intramyocellular lipid content in the participants' leg muscle measured by 31phosphorus- and 1proton-MRS, respectively, were significantly elevated in the CHF patients, indicating abnormal intramuscular energy metabolism. Notably, the skeletal muscle abnormalities were related to the enhanced systemic oxidative stress. Our analyses revealed that systemic oxidative stress is related to lowered whole-body aerobic capacity and skeletal muscle dysfunction in CHF patients.
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影响因子：
16.2
作者：
Yokota T;Kinugawa S;Yamato M;Hirabayashi K;Suga T;Takada S;Harada K;Morita N;Oyama-Manabe N;Kikuchi Y;Okita K;Tsutsui H
通讯作者：
Tsutsui H
影响因子：
24
作者：
Wilson Tang, W. H.;Tong, Wilson;Klein, Allan L.
通讯作者：
Klein, Allan L.
影响因子：
37.8
作者：
Maack, C;Kartes, T;Laufs, U
通讯作者：
Laufs, U
影响因子：
3.4
作者：
Bouzid, Mohamed Amine;Hammouda, Omar;Fabre, Claudine
通讯作者：
Fabre, Claudine
影响因子：
20.1
作者：
Ide, T;Tsutsui, H;Takeshita, A
通讯作者：
Takeshita, A