Gamma and Ion-Beam Irradiation of DNA: Free Radical Mechanisms, Electron Effects, and Radiation Chemical Track Structure.
Gamma and Ion-Beam Irradiation of DNA: Free Radical Mechanisms, Electron Effects, and Radiation Chemical Track Structure.
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DOI：
10.1016/j.radphyschem.2016.04.022
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Adhikary A
中科院分区：
文献类型：
--
作者：
Sevilla MD;Becker D;Kumar A;Adhikary A
我们实验室的研究重点是研究γ射线和离子束辐射诱导的DNA自由基过程导致的直接型DNA损伤机制，这些自由基过程导致对细胞存活至关重要的分子损伤。本工作比较了低LET（γ-）和高LET（离子束）辐射的结果，以建立离子束辐射损伤DNA的化学径迹结构模型。介绍了N1取代胞嘧啶衍生物中胞嘧啶阳离子自由基在基态和5-甲基胞嘧啶阳离子自由基在基态和激发态质子化状态的研究进展。我们的结果显示了5-甲基胞嘧啶阳离子自由基的激发自由基签名。此外，我们最近的理论研究阐明了电子诱导反应（低能电子（LEE），预溶剂化电子（epre-）和水（或溶剂化）电子（eaq-））的作用。最后，DFT计算的各种糖自由基的电离势显示这些物种的相对反应性。
The focus of our laboratory’s investigation is to study the direct-type DNA damage mechanisms resulting from γ-ray and ion-beam radiation-induced free radical processes in DNA which lead to molecular damage important to cellular survival. This work compares the results of low LET (γ−) and high LET (ion-beam) radiation to develop a chemical track structure model for ion-beam radiation damage to DNA. Recent studies on protonation states of cytosine cation radicals in the N1-substituted cytosine derivatives in their ground state and 5-methylcytosine cation radicals in ground as well as in excited state are described. Our results exhibit a radical signature of excitations in 5-methylcytosine cation radical. Moreover, our recent theoretical studies elucidate the role of electron-induced reactions (low energy electrons (LEE), presolvated electrons (epre−), and aqueous (or, solvated) electrons (eaq−)). Finally DFT calculations of the ionization potentials of various sugar radicals show the relative reactivity of these species.
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影响因子：
15
作者：
Adhikary A;Khanduri D;Sevilla MD
通讯作者：
Sevilla MD
影响因子：
3.3
作者：
Adhikary, Amitava;Becker, David;Palmer, Brian J.;Heizer, Alicia N.;Sevilla, Michael D.
通讯作者：
Sevilla, Michael D.
影响因子：
15
作者：
Adhikary, Amitava;Kumar, Anil;Rayala, Ramanjaneyulu;Hindi, Ragda M.;Adhikary, Ananya;Wnuk, Stanislaw F.;Sevilla, Michael D.
通讯作者：
Sevilla, Michael D.
影响因子：
2.9
作者：
Close, David M.
通讯作者：
Close, David M.
影响因子：
15
作者：
Boussicault, Fabien;Kaloudis, Panagiotis;Chatgilialoglu, Chryssostomos
通讯作者：
Chatgilialoglu, Chryssostomos