Comparison of the laboratory data between Kawasaki disease and enterovirus after intravenous immunoglobulin treatment.
Comparison of the laboratory data between Kawasaki disease and enterovirus after intravenous immunoglobulin treatment.
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DOI：
10.1007/s00246-012-0293-9
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发表时间：
2012-12
影响因子：
1.6
通讯作者：
Kuo HC
中科院分区：
文献类型：
--
作者：
Lin LY;Yang TH;Lin YJ;Yu HR;Yang KD;Huang YC;Chang WC;Kuo HC
川崎病是一种病因不明的全身性脉管炎。对KD患者静脉注射免疫球蛋白(IVIG)前后的实验室检查结果进行了讨论，但IVIG治疗的特点尚不清楚。本研究旨在比较KD患者和肠道病毒(EV)感染患者的实验室数据，以评估IVIG治疗后的差异。这项研究纳入了从2003年到2010年接受单剂IVIG治疗的171名KD患者和38名EV患者。分析实验室数据，包括总白细胞计数(WBC)和血红蛋白(Hb)、血小板、节段、淋巴细胞、嗜酸性粒细胞和单核细胞水平。与KD患者相比，IVIG治疗前EV患者的Hb、淋巴细胞和单核细胞水平较高，嗜酸性粒细胞水平较低(P<0.05)。在IVIG治疗后，KD患者的Hb和片段水平低于EV患者，而血小板、淋巴细胞和嗜酸性粒细胞水平高于EV患者(P<0.05)。在KD患者中，静脉注射免疫球蛋白治疗后，血小板、嗜酸性粒细胞和单核细胞水平升高，而Hb、WBC和部分水平显著下降(P<0.001)。在EV患者中，IVIG治疗后嗜酸性粒细胞水平升高，而WBC和Hb水平显著下降(P<0.05)。本研究结果为KD和EV患者的嗜酸性粒细胞增多症可能与IVIG治疗有关提供了证据。KD患者IVIG治疗前后的嗜酸性粒细胞水平均高于EV患者，这可能与KD的炎症机制有关。KD患者的血小板水平高于EV患者，提示血小板参与了KD的炎症反应。
Kawasaki disease (KD) is a systemic vasculitis of unknown etiology. The laboratory findings before and after intravenous immunoglobulin (IVIG) in KD have been discussed, but the characteristics of IVIG therapy still are unclear. This study aimed to compare laboratory data from patients with KD and enterovirus (EV) infection to evaluate the differences after IVIG therapy. The study enrolled 171 KD patients and 38 EV patients treated with a single dose of IVIG from 2003 to 2010. Laboratory data including total white blood cell counts (WBC) and hemoglobin (Hb), platelet, segment, lymphocyte, eosinophil, and monocyte levels were analyzed. Compared with the KD patients, the EV patients had higher Hb, lymphocyte, and monocyte levels and lower eosinophil levels before IVIG treatment (p < 0.05). After IVIG treatment, the KD patients had lower Hb and segment levels but higher platelet, lymphocyte, and eosinophil levels than the EV patients (p < 0.05). In the KD patients, the platelet, eosinophil, and monocyte levels increased after IVIG treatment, whereas Hb, WBC, and segment levels decreased significantly (p < 0.001). In the EV patients, eosinophil levels increased after IVIG treatment, whereas WBC and Hb levels decreased significantly (p < 0.05). The study results provide evidence that eosinophilia may be related to IVIG therapy in KD and EV patients. The KD patients had higher eosinophil levels both before and after IVIG therapy than the EV patients, which may have been due to the inflammatory mechanism of KD. The KD patients had higher platelet levels than the EV patients, suggesting that platelets are involved in the inflammatory response to KD.
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影响因子：
4.4
作者：
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通讯作者：
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影响因子：
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通讯作者：
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作者：
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通讯作者：
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