Consumers' use of web-based information and their decisions about multiplex genetic susceptibility testing.
Consumers' use of web-based information and their decisions about multiplex genetic susceptibility testing.
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DOI：
10.2196/jmir.1587
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发表时间：
2010-09-29
影响因子：
7.4
通讯作者：
Baxevanis AD
中科院分区：
文献类型：
--
作者：
Kaphingst KA;McBride CM;Wade C;Alford SH;Brody LC;Baxevanis AD
很少有数据能够告知在线直接面向消费者的遗传易感性测试营销所引起的担忧，例如23andme，Navigenics和DNA Direct等商业实体提供的测试。多重倡议，健康成人的人群为基础的研究，提供了第一次机会，以评估如何使用基于网络的决策工具，传达有关遗传易感性测试的信息影响个人的测试决定。告知正在进行的辩论是否个人提供的遗传易感性测试没有医疗保健提供者的参与（例如，通过直接面向消费者的测试）可以作出明智的决定时，在线决策辅助工具的测试。参与者是526名年龄在25岁至40岁之间的大型健康维护组织成员，他们访问了一个研究网站。多元逻辑回归模型进行了测试，以检查网站使用与下游测试决策的关联。参与者平均浏览了介绍多重测试的4页中的2.9页，描述健康状况的8页中的2.2页，描述基因的15页中的3.2页。对于每一个浏览的页面，参与者更有可能描述他们的决策是容易的（比值比[OR] 1.04，95%置信区间[CI] 1.01-1.07），并决定接受测试（OR 1.08，95% CI 1.05-1.11）。在这项研究中，健康的成年人认为基于网络的基因组信息，使用循证通信的方法，是有助于支持两个决定测试和不测试。需要继续进行研究，以确保这些结果推广到识字率较低和不太了解互联网的目标群体。
Few data exist to inform concerns raised by online direct-to-consumer marketing of genetic susceptibility tests, such as those offered by commercial entities like 23andme, Navigenics, and DNA Direct. The Multiplex Initiative, a population-based study of healthy adults, provides the first opportunity to evaluate how use of a Web-based decision tool that conveyed information about a genetic susceptibility test influenced individuals’ test decisions. To inform the ongoing debate over whether individuals offered genetic susceptibility testing without the involvement of a health care provider (eg, through direct-to-consumer testing) can make informed decisions about testing when guided by online decision aids. Participants were 526 members of a large health maintenance organization aged 25 to 40 years old who visited a study website. Multivariate logistic regression models were tested to examine the association of website usage with downstream test decisions. Participants viewed an average of 2.9 of the 4 pages introducing the multiplex test, 2.2 of the 8 pages describing the health conditions, and 3.2 of the 15 pages describing the genes. For each page viewed, participants were more likely to describe their decision-making as easy (odds ratio [OR] 1.04, 95% confidence interval [CI] 1.01-1.07) and to decide to be tested (OR 1.08, 95% CI 1.05-1.11). Healthy adults in this study perceived Web-based genomic information presented using evidence-based communications approaches to be helpful in supporting both decisions to test and not to test. Continued research is needed to ensure that these results generalize to target groups with lower literacy and less Internet savvy.
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影响因子：
7.6
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