Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study.
Fatty acid desaturase (FADS) gene polymorphisms and insulin resistance in association with serum phospholipid polyunsaturated fatty acid composition in healthy Korean men: cross-sectional study.
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DOI：
10.1186/1743-7075-8-24
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发表时间：
2011-04-23
影响因子：
4.5
通讯作者：
Lee JH
中科院分区：
文献类型：
--
作者：
Kim OY;Lim HH;Yang LI;Chae JS;Lee JH
我们调查了脂肪酸去饱和酶（FADS）基因多态性和胰岛素抵抗（IR）与健康韩国男性血清磷脂多不饱和脂肪酸（FA）组成之间的关系。对576例30 ~ 79岁健康男性进行了rs 174537位点FADS 1（FEN 1 - 10154 G>T）、FADS 2（rs 174575 C>G、rs 2727270 C>T）和FADS 3（rs 1000778 C>T）SNP分型。测定膳食摄入量、血清磷脂脂肪酸组成和HOMA-IR。rs 174575 G等位基因携带者空腹胰岛素和HOMA-IR显著高于CC纯合子，而rs 2727270 T等位基因携带者空腹胰岛素和HOMA-IR显著低于CC纯合子。FEN 1 - 10154 G>T、rs 174575 C>G和rs 2727270 C>T的次要等位基因携带者的亚油酸（18：2ω-6，LA）比例分别高于主要纯合子。而FEN 1 -10154 G>T和rs 2727270 C>T的次要等位基因携带者的血清磷脂中二高-γ-亚麻酸（20：3ω-6，DGLA）和花生四烯酸（20：4ω-6，AA）的比例分别显著低于主要纯合子。rs 1000778 T等位基因携带者AA也显著低于CC纯合子。HOMA-IR与LA、DGLA呈正相关，与AA/DGLA呈负相关。有趣的是，rs 174575 G等位基因携带者的HOMA-IR显著高于CC纯合子，此时受试者的DLGA比例（≥1.412%，占总血清磷脂FA组成）（相互作用P = 0.009）或AA比例（≥4.573%，相互作用P = 0.047）较高。HOMA-IR与FADS基因簇以及血清磷脂中的FA组成相关。此外，HOMA-IR可通过rs 174575 C>G与血清磷脂中DGLA或AA的比例之间的相互作用来调节。
We investigated the relationship between fatty acid desaturase (FADS) gene polymorphisms and insulin resistance (IR) in association with serum phospholipid polyunsaturated fatty acid (FA) composition in healthy Korean men. Healthy men (n = 576, 30 ~ 79 years old) were genotyped for rs174537 near FADS1 (FEN1-10154G>T), FADS2 (rs174575C>G, rs2727270C>T), and FADS3 (rs1000778C>T) SNPs. Dietary intake, serum phospholipid FA composition and HOMA-IR were measured. Fasting insulin and HOMA-IR were significantly higher in the rs174575G allele carriers than the CC homozygotes, but lower in the rs2727270T allele carriers than the CC homozygotes. The proportion of linoleic acid (18:2ω-6, LA) was higher in the minor allele carriers of FEN1-10154G>T, rs174575C>G and rs2727270C>T than the major homozygotes, respectively. On the other hand, the proportions of dihomo-γ-linolenic acid (20:3ω-6, DGLA) and arachidonic acid (20:4ω-6, AA) in serum phospholipids were significantly lower in the minor allele carriers of FEN1-10154 G>T carriers and rs2727270C>T than the major homozygotes respectively. AA was also significantly lower in the rs1000778T allele carriers than the CC homozygotes. HOMA-IR positively correlated with LA and DGLA and negatively with AA/DGLA in total subjects. Interestingly, rs174575G allele carriers showed remarkably higher HOMA-IR than the CC homozygotes when subjects had higher proportions of DLGA (≥1.412% in total serum phospholipid FA composition) (P for interaction = 0.009) or of AA (≥4.573%) (P for interaction = 0.047). HOMA-IR is associated with FADS gene cluster as well as with FA composition in serum phospholipids. Additionally, HOMA-IR may be modulated by the interaction between rs174575C>G and the proportion of DGLA or AA in serum phospholipids.
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影响因子：
7.7
作者：
Iwaki, M;Matsuda, M;Shimomura, I
通讯作者：
Shimomura, I
影响因子：
6.5
作者：
Fu, YC;Luo, NL;Garvey, WT
通讯作者：
Garvey, WT
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影响因子：
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作者：
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通讯作者：
IACONO, JM
影响因子：
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作者：
Krey, G;Braissant, O;Wahli, W
通讯作者：
Wahli, W