Mild-moderate CKD is not associated with cognitive impairment in older adults in the Alzheimer's Disease Neuroimaging Initiative cohort.
Mild-moderate CKD is not associated with cognitive impairment in older adults in the Alzheimer's Disease Neuroimaging Initiative cohort.
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DOI：
10.1371/journal.pone.0239871
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发表时间：
2020
期刊：
影响因子：
3.7
通讯作者：
Alzheimer’s Disease Neuroimaging Initiative
中科院分区：
文献类型：
--
作者：
Gupta A;Kennedy K;Perales-Puchalt J;Drew D;Beddhu S;Sarnak M;Burns J;Alzheimer’s Disease Neuroimaging Initiative
慢性肾脏病（CKD）与认知障碍和痴呆有关。我们研究了这种关系在老年人中是否成立，因为老年人的慢性肾病和痴呆症患病率较高。我们对已建立的观察队列进行了横断面二次分析。我们分析了阿尔茨海默病神经影像计划 (ADNI) 的数据，这是一项 NIH 资助的多中心纵向观察研究，其中包括认知正常和受损的参与者，并通过一系列全面的神经心理学测试来评估认知。我们纳入了所有在基线时进行血清肌酐测量的 ADNI 参与者的非概率样本 (N = 1181)。使用多变量线性回归分析，我们将 CKD 流行病学协作方程 eGFR 与经过验证的记忆力 (ADNI-mem) 和执行功能 (ADNI-EF) 综合得分相关联。 1181 名 ADNI 参与者的平均年龄为 73.7 ± 7.1 岁。平均估计肾小球滤过率 (eGFR) 为 76.4 ± 19.7； 6% 的 eGFR<45，22% 的 eGFR 为 45 至 <60，51% 的 eGFR 为 60-90，21% 的 eGFR>90 ml/min/1.73 m2。平均 ADNI-Mem 评分为 0.241 ± 0.874，平均 ADNI-EF 评分为 0.160 ± 1.026。在单独的多变量线性回归模型中，根据年龄、性别、种族教育和 BMI 进行调整后，eGFR 每升高 10 ml/min/1.73 m2 与 ADNI-Mem (β -0.02, 95% CI -0.04, 0.02, p = 0.56) 或 ADNI-EF (β 0.01, 95% CI -0.03, 0.05, p = ) 之间没有关联。 0.69）分数。我们没有观察到老年 ADNI 参与者的 eGFR 与认知之间存在关联。
Chronic kidney disease (CKD) is associated with cognitive impairment and dementia. We examined whether this relationship hold true in older adults, who have a higher prevalence of both CKD and dementia. We conducted a cross-sectional secondary analysis of an established observational cohort. We analyzed data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI), an NIH funded, multicenter longitudinal observational study, which includes participants with normal and impaired cognition and assesses cognition with a comprehensive battery of neuropsychological tests. We included a non-probability sample of all ADNI participants with serum creatinine measurements at baseline (N = 1181). Using multivariable linear regression analysis, we related the CKD Epidemiology Collaboration equation eGFR with validated composite scores for memory (ADNI-mem) and executive function (ADNI-EF). For the 1181 ADNI participants, the mean age was 73.7 ± 7.1 years. Mean estimated glomerular filtration rate (eGFR) was 76.4 ± 19.7; 6% had eGFR<45, 22% had eGFR of 45 to <60, 51% had eGFR of 60–90 and 21% had eGFR>90 ml/min/1.73 m2. The mean ADNI-Mem score was 0.241 ± 0.874 and mean ADNI-EF score was 0.160 ± 1.026. In separate multivariable linear regression models, adjusted for age, sex, race education and BMI, there was no association between each 10 ml/ min/1.73 m2 higher eGFR and ADNI-Mem (β -0.02, 95% CI -0.04, 0.02, p = 0.56) or ADNI-EF (β 0.01, 95% CI -0.03, 0.05, p = 0.69) scores. We did not observe an association between eGFR and cognition in the older ADNI participants.
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DOI：
10.1053/j.ajkd.2016.11.015
发表时间：
2017-06
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Drew DA;Weiner DE;Tighiouart H;Duncan S;Gupta A;Scott T;Sarnak MJ
通讯作者：
Sarnak MJ
影响因子：
3.2
作者：
Crane, Paul K.;Carle, Adam;Gibbons, Laura E.;Insel, Philip;Mackin, R. Scott;Gross, Alden;Jones, Richard N.;Mukherjee, Shubhabrata;Curtis, S. McKay;Harvey, Danielle;Weiner, Michael;Mungas, Dan
通讯作者：
Mungas, Dan
DOI：
10.1053/j.ajkd.2009.12.016
发表时间：
2010-04
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
Matsushita K;Selvin E;Bash LD;Astor BC;Coresh J
通讯作者：
Coresh J
影响因子：
13.6
作者：
Fan, Li;Levey, Andrew S.;Inker, Lesley A.
通讯作者：
Inker, Lesley A.
影响因子：
120.7
作者：
Hallan, Stein I.;Matsushita, Kunihiro;Sang, Yingying;Mahmoodi, Bakhtawar K.;Black, Corri;Ishani, Areef;Kleefstra, Nanne;Naimark, David;Roderick, Paul;Tonelli, Marcello;Wetzels, Jack F. M.;Astor, Brad C.;Gansevoort, Ron T.;Levin, Adeera;Wen, Chi-Pang;Coresh, Josef
通讯作者：
Coresh, Josef