Distinguishing spinocerebellar ataxia with pure cerebellar manifestation from multiple system atrophy (MSA-C) through saccade profiles
Distinguishing spinocerebellar ataxia with pure cerebellar manifestation from multiple system atrophy (MSA-C) through saccade profiles
复制标题
通过眼跳图区分具有纯小脑表现的脊髓小脑共济失调和多系统萎缩 (MSA-C)
DOI：
10.1016/j.clinph.2016.10.012
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Ugawa Y
中科院分区：
文献类型：
--
作者：
Terao Y;Fukuda H;Tokushige SI;Inomata-Terada S;Yugeta A;Hamada M;Ugawa Y
脊髓小脑性共济失调伴单纯小脑先露（SCD）和多系统萎缩（MSA-C）的患者在早期表现出相似的症状，尽管SCD中以离小脑病理为主，MSA-C中以向小脑病理为主。我们研究了是否扫视速度轮廓，反映了小脑的加速和制动功能，可以区分这两个disorders.MethodsWe记录视觉引导（VGS）和记忆引导扫视（MGS）在29例MSA-C患者，12例SCD患者，和92名年龄匹配的正常人，并比较其幅度，结果MSA-C的VGS和MGS以短距为主，SCD以短距为主，MGS以短距为主。在较小的靶偏心率下，SCD组和MSA-C组的峰值流速降低，并随着疾病的进展而恶化。减速阶段延长SCD相比，MSA-C和正常组在更大的目标偏心率，恶化与推进diseases.ConclusionSaccades在MSA-C的特点是由一个更突出的加速赤字和那些在SCD由一个更突出的制动缺陷，可能引起的小脑和小脑离的病理，显著性扫视轮廓提供了关于脊髓小脑性共济失调中小脑的加速和制动信号的重要信息。
ObjectivePatients with spinocerebellar ataxia with pure cerebellar presentation (SCD) and multiple system atrophy (MSA-C) show similar symptoms at early stages, although cerebellofugal pathology predominates in SCD, and cerebellopetal pathology in MSA-C. We studied whether saccade velocity profiles, which reflect the accelerating and braking functions of the cerebellum, can differentiate these two disorders.MethodsWe recorded visually guided (VGS) and memory guided saccades (MGS) in 29 MSA-C patients, 12 SCD patients, and 92 age-matched normal subjects, and compared their amplitude, peak velocity and duration (accelerating and decelerating phases).ResultsHypometria predominated in VGS and MGS of MSA-C, whereas hypometria was less marked in SCD, with hypermetria frequently noted in MGS. Peak velocity was reduced, and deteriorated with advancing disease both in SCD and MSA-C groups at smaller target eccentricities. The deceleration phase was prolonged in SCD compared to MSA-C and normal groups at larger target eccentricities, which deteriorated with advancing disease.ConclusionSaccades in MSA-C were characterized by a more prominent acceleration deficit and those in SCD by a more prominent braking defect, possibly caused by the cerebellopetal and cerebellofugal pathologies, respectively.SignificanceSaccade profiles provide important information regarding the accelerating and braking signals of the cerebellum in spinocerebellar ataxia.
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影响因子：
2.5
作者：
J. Quinet;Laurent Goffart
通讯作者：
J. Quinet;Laurent Goffart
橄榄脑桥小脑萎缩（多系统萎缩）中 Leu-7 阳性胶质细胞的嗜银泛素化胞质包涵体
影响因子：
12.7
作者：
S. Kato;H. Nakamura;Asao Hirano;Hidefumi Ito;J. F. Llena;S. Yen
通讯作者：
S. Yen
影响因子：
3.3
作者：
DEAN, P
通讯作者：
DEAN, P
弗里德赖希共济失调的动眼神经异常
DOI：
10.1017/s0317167100119584
发表时间：
1979
期刊：
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
影响因子：
--
作者：
T. H. Kirkham;D. Guitton;A. Katsarkas;L. B. Kline;E. Andermann
通讯作者：
E. Andermann
16q-ADCA 与 SCA8 重复扩增共存的严重症状
DOI：
--
发表时间：
2008
期刊：
Journal of Neurological Sciences
影响因子：
--
作者：
K. Ohnari;M. Aoki;T. Uozumi;S. Tsuji
通讯作者：
S. Tsuji