Ceramide-1-phosphate regulates migration of multipotent stromal cells and endothelial progenitor cells--implications for tissue regeneration.
Ceramide-1-phosphate regulates migration of multipotent stromal cells and endothelial progenitor cells--implications for tissue regeneration.
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DOI：
10.1002/stem.1291
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发表时间：
2013-03
期刊：
影响因子：
5.2
通讯作者：
Ratajczak, Mariusz Z.
中科院分区：
文献类型：
--
作者：
Kim, Chihwa;Schneider, Gabriela;Abdel-Latif, Ahmed;Mierzejewska, Kasia;Sunkara, Manjula;Borkowska, Sylwia;Ratajczak, Janina;Morris, Andrew J.;Kucia, Magda;Ratajczak, Mariusz Z.
关键词：
神经酰胺-1-磷酸（C1 P）是一种生物活性脂质，与神经酰胺相反，它是一种从受损和“泄漏”的细胞释放的抗凋亡分子。如最近报道的，C1 P促进造血细胞的迁移。在目前的论文中，我们测试的假设，C1 P组织损伤后释放可能发挥低估的作用，在各种类型的干细胞和内皮细胞参与组织/器官再生的化学吸引。我们首次发现C1 P在受损组织中上调，并吸引BM衍生的多能基质细胞（MSC），内皮祖细胞（EPCs）和非常小的胚胎样干细胞（VSELs）。此外，与其他生物活性脂质相比，C1 P更有效地化学吸引人脐静脉内皮细胞（HUVECs），并刺激这些细胞的管形成。C1 P还促进Matrigel植入物的体内血管化，并刺激BM衍生的成纤维细胞分泌基质衍生因子-1（SDF-1）。因此，我们的数据首次表明，C1 P是一种从受损细胞释放的有效生物活性脂质，在招募干/祖细胞到受损器官中可能发挥重要和新颖的作用，并可能促进其血管化。
Ceramide-1-phosphate (C1P) is a bioactive lipid that, in contrast to ceramide, is an anti-apoptotic molecule released from cells that are damaged and “leaky”. As reported recently, C1P promotes migration of hematopoietic cells. In the current paper, we tested the hypothesis that C1P released upon tissue damage may play an underappreciated role in chemoattraction of various types of stem cells and endothelial cells involved in tissue/organ regeneration. We show for a first time that C1P is upregulated in damaged tissues and chemoattracts BM-derived multipotent stroma cells (MSCs), endothelial progenitor cells (EPCs), and very small embryonic-like stem cells (VSELs). Furthermore, compared to other bioactive lipids, C1P more potently chemoattracted human umbilical vein endothelial cells (HUVECs) and stimulated tube formation by these cells. C1P also promoted in vivo vascularization of Matrigel implants and stimulated secretion of stromal derived factor-1 (SDF-1) from BM-derived fibroblasts. Thus, our data demonstrate, for the first time, that C1P is a potent bioactive lipid released from damaged cells that potentially plays an important and novel role in recruitment of stem/progenitor cells to damaged organs and may promote their vascularization.
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影响因子：
11.2
作者：
Dome, Balazs;Timar, Jozsef;Tovari, Jozsef
通讯作者：
Tovari, Jozsef
影响因子：
4.8
作者：
Haenel, Petra;Andreani, Paul;Graeler, Markus H.
通讯作者：
Graeler, Markus H.
影响因子：
7.8
作者：
George, Jon C.
通讯作者：
George, Jon C.
DOI：
10.1159/000329397
发表时间：
2011-01-01
期刊：
CONTROVERSIES IN ACUTE KIDNEY INJURY
影响因子：
--
作者：
Camussi, Giovanni;Cantaluppi, Vincenzo;Tetta, Ciro
通讯作者：
Tetta, Ciro
影响因子：
2.6
作者：
Baj-Krzyworzeka, M;Majka, M;Ratajczak, MZ
通讯作者：
Ratajczak, MZ