Cell signaling in space and time: where proteins come together and when they're apart.

Cell signaling in space and time: where proteins come together and when they're apart.
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时空信号传导:蛋白质聚集在一起以及它们分开的位置。

DOI:
10.1126/science.1175668
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发表时间:
2009-11-27
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Pawson T
Pawson T
中科院分区:
其他
文献类型:
--
作者:
Scott JD;Pawson T

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信号转导可以被定义为从细胞外线索到细胞内效应器的信息的协调传递。更简单地说,细胞表面接收到的信息通过质膜进行处理,并传输到细胞内的靶点。这需要对细胞信号做出反应的激活剂、效应器、酶和底物在需要时聚集在一起。
Signal transduction can be defined as the coordinated relay of messages derived from extracellular cues to intracellular effectors. More simply put, information received on the cell surface is processed across the plasma membrane and transmitted to intracellular targets. This requires that the activators, effectors, enzymes, and substrates that respond to cellular signals come together when they need to.
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