Immunosenescence of Polymorphonuclear Neutrophils
Immunosenescence of Polymorphonuclear Neutrophils
复制标题
多形核中性粒细胞的免疫衰老
DOI：
--
复制
发表时间：
2010
影响因子：
--
通讯作者：
P. Uciechowski
中科院分区：
文献类型：
--
作者：
I. Wessels;J. Jansen;L. Rink;P. Uciechowski
所有免疫细胞都受到衰老的影响，导致老年人对感染的易感性增加，死亡率增加。衰老对适应性免疫系统细胞的影响有充分的文献记载。相反，关于年龄相关的多形核中性粒细胞（PMN）缺陷的知识有限。在过去的十年中，它已经变得明显，除了其作为吞噬细胞的传统作用，中性粒细胞能够分泌广泛的免疫调节分子。导致中性粒细胞减少症的遗传缺陷增加了对感染的易感性，这一发现强调了它们的重要性。尽管在衰老过程中PMN循环数量恒定的观点是一致的，但对老年供体PMN的组织浸润、吞噬和氧化爆发能力的讨论仍存在争议。此外，体内和体外结果之间以及鼠和人PMN的结果之间存在许多差异。大多数报道的功能变化可以通过有缺陷的信号通路来解释，但需要进一步的研究来详细了解潜在的分子机制。这可以成为药物开发的基础，以预防或治疗与年龄有关的疾病，从而减轻公共卫生系统的负担。
All immune cells are affected by aging, contributing to the high susceptibility to infections and increased mortality observed in the elderly. The effect of aging on cells of the adaptive immune system is well documented. In contrast, knowledge concerning age-related defects of polymorphonuclear neutrophils (PMN) is limited. During the past decade, it has become evident that in addition to their traditional role as phagocytes, neutrophils are able to secrete a wide array of immunomodulating molecules. Their importance is underlined by the finding that genetic defects that lead to neutropenia increase susceptibility to infections. Whereas there is consistence about the constant circulating number of PMN throughout aging, the abilities of tissue infiltration, phagocytosis, and oxidative burst of PMN from aged donors are discussed controversially. Furthermore, there are numerous discrepancies between in vivo and in vitro results, as well as between results for murine and human PMN. Most of the reported functional changes can be explained by defective signaling pathways, but further research is required to get a detailed insight into the underlying molecular mechanisms. This could form the basis for drug development in order to prevent or treat age-related diseases, and thus to unburden the public health systems.
登录
查看更多内容
影响因子：
16.8
作者：
Chen WH;Kozlovsky BF;Effros RB;Grubeck-Loebenstein B;Edelman R;Sztein MB
通讯作者：
Sztein MB
DOI：
10.1016/j.jnutbio.2009.06.008
发表时间：
2009-12
期刊：
The Journal of nutritional biochemistry
影响因子：
--
作者：
Kim KC;Friso S;Choi SW
通讯作者：
Choi SW
影响因子：
9.6
作者：
Vandivier, R. William;Henson, Peter M.;Douglas, Ivor S.
通讯作者：
Douglas, Ivor S.
粒细胞/巨噬细胞集落刺激因子、IFN-γ 和 IL-3 对人多形核中性粒细胞诱导 MHC II 类。
DOI：
--
发表时间：
1993
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Gosselin,EJ;Wardwell,K;Rigby,WF;Guyre,PM
通讯作者：
Guyre,PM
影响因子：
6.5
作者：
Swift, ME;Burns, AL;DiPietro, LA
通讯作者：
DiPietro, LA