Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination.
Insulin/IGF-1 and ROS signaling pathway cross-talk in aging and longevity determination.
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DOI：
10.1016/j.mce.2008.11.025
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发表时间：
2009-02-05
影响因子：
4.1
通讯作者：
Papaconstantinou J
中科院分区：
文献类型：
--
作者：
Papaconstantinou J
激素、胰岛素/IGF-1 （Ins/IGF-1）信号活性的调节以及活性氧（ROS）的内在生成途径在衰老和寿命决定中发挥作用。在这篇综述中，我们讨论了这些信号通路之间的相互作用，这些信号通路可能是调节衰老和长寿的重要因素。几种小鼠突变体中控制衰老和长寿速率的生理过程的平衡表明，胰岛素/IGF1信号通路与ROS信号通路的调节可能存在串扰机制。在小鼠中，由Prop1df、Pit1dw和Igf1受体突变引起的Ins/IGF-1信号通路的调节是与衰老和寿命决定相关的激素通路的例证。这些途径也是ros介导的氧化还原途径的靶点。同样，Klotho和p66Shc突变体将ROS信号通路的调节与衰老和寿命的决定联系起来。这两种模型也显示出胰岛素信号活动的改变，这是与长寿有关的特征。Ins/IGF-1信号通路特别有趣，因为它的活性由于基因操作而降低，而不是对ROS水平的反应。
Regulation of hormonal, insulin/IGF-1 (Ins/IGF-1) signaling activities, and pathways of the intrinsic generation of reactive oxygen species (ROS) play a role in aging and longevity determination. In this review we discuss the cross-talk between these pathways as mechanisms of signaling that may be important factors in the regulation of aging and longevity. The balance of physiological processes controlling the rate of aging and longevity in several mouse mutants suggests the involvement of cross-talk mechanisms of regulation of the insulin/IGF1 signaling pathway vs. the ROS signaling pathways. In mice, modulation of the Ins/IGF-1 signaling pathways resulting from the Prop1df, Pit1dw and Igf1 receptor mutations exemplify the hormonal pathways associated with aging and longevity determination. These pathways are also targets of the ROS-mediated redox pathways. Similarly, the Klotho and p66Shc mutants link regulation of ROS signaling pathways to aging and longevity determination. Both of these models also display altered insulin signaling activity, a characteristic associated with longevity. The Ins/IGF-1 signaling pathway is of particular interest because of its decreased activity due to genetic manipulation vs. its responsiveness to ROS levels.
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影响因子：
3.9
作者：
Bartke, A;Brown-Borg, HM;Bronson, RT
通讯作者：
Bronson, RT
DOI：
10.1152/ajpendo.1998.274.2.e309
发表时间：
1998-02-01
影响因子：
5.1
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作者：
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影响因子：
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作者：
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