Psychosocial Stress, Cortisol Levels, and Maintenance of Vaginal Health.
Psychosocial Stress, Cortisol Levels, and Maintenance of Vaginal Health.
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DOI：
10.3389/fendo.2018.00568
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发表时间：
2018
影响因子：
5.2
通讯作者：
Anumba DOC
中科院分区：
文献类型：
--
作者：
Amabebe E;Anumba DOC
压力刺激无处不在，女性也不例外。如果压力刺激持续的时间超过了必要的时间，生理上的“战斗或逃跑”反应可能对女性下生殖道微生物群有害。持续暴露于社会心理压力和刺激下丘脑-垂体-肾上腺（HPA）和交感-肾上腺-髓质（SAM）轴以及相关激素是包括泌尿生殖道感染在内的几种感染的危险因素。虽然这可能是由于免疫反应失调，但皮质醇诱导的阴道糖原沉积抑制可能涉及阴道感染的情况。雌激素相关的阴道糖原增加和上皮细胞成熟是维持健康的阴道生态系统（益生菌）所必需的。动物模型表明，皮质醇破坏这一过程的能力在阴道生态失调的发病机制和随后的感染和炎症的发展中是重要的。这种现象在怀孕期间可能更为重要，因为健康的乳酸杆菌主导的阴道微生物群是神圣不可侵犯的，并且从蜕膜、胎膜和胎盘中产生更多的促肾上腺皮质激素释放激素（CRH）。为了强调应激激素皮质醇与阴道微生物结构和功能之间的关系，我们研究了皮质醇在维持阴道健康中的潜在作用。
Stress stimuli are ubiquitous and women do not enjoy any exemptions. The physiologic “fight-or-flight” response may be deleterious to the female lower genital tract microbiome if the stress stimuli persist for longer than necessary. Persistent exposure to psychosocial stress and stimulation of the hypothalamic-pituitary-adrenal (HPA) and sympathetic-adrenal-medullary (SAM) axes, and associated hormones are risk factors for several infections including genitourinary tract infections. Though this could be due to a dysregulated immune response, a cortisol-induced inhibition of vaginal glycogen deposition may be involved especially in the instance of vaginal infection. The estrogen-related increased vaginal glycogen and epithelial maturation are required for the maintenance of a healthy vaginal ecosystem (eubiosis). The ability of cortisol to disrupt this process as indicated in animal models is important in the pathogenesis of vaginal dysbiosis and the subsequent development of infection and inflammation. This phenomenon may be more crucial in pregnancy where a healthy Lactobacillus-dominated vaginal microbiota is sacrosanct, and there is local production of more corticotropin-releasing hormone (CRH) from the decidua, fetal membranes and placenta. To highlight the relationship between the stress hormone cortisol and the vaginal microbiomial architecture and function, the potential role of cortisol in the maintenance of vaginal health is examined.
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影响因子：
2.7
作者：
Brauer, M. Monica;Smith, Peter G.
通讯作者：
Smith, Peter G.
影响因子：
3.9
作者：
Amabebe E;Anumba DOC
通讯作者：
Anumba DOC
DOI：
10.1111/j.1479-828x.2000.tb03344.x
发表时间：
2000-08-01
影响因子：
1.7
作者：
Austin, MP;Leader, L
通讯作者：
Leader, L
DOI：
10.1016/s0889-8529(18)30191-9
发表时间：
1992-12-01
影响因子：
4.5
作者：
CHROUSOS, GP
通讯作者：
CHROUSOS, GP
影响因子：
3.3
作者：
Brosnahan, Amanda J.;Vulchanova, Lucy;Witta, Samantha R.;Dai, Yuying;Jones, Bryan J.;Brown, David R.
通讯作者：
Brown, David R.