The Vaginal Microenvironment: The Physiologic Role of Lactobacilli.
The Vaginal Microenvironment: The Physiologic Role of Lactobacilli.
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DOI：
10.3389/fmed.2018.00181
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发表时间：
2018
影响因子：
3.9
通讯作者：
Anumba DOC
中科院分区：
文献类型：
--
作者：
Amabebe E;Anumba DOC
除了作为精子，阴道和婴儿的通道外，人类阴道及其微生物群还可以影响受孕，怀孕，分娩方式和时间以及获得性传播感染的风险。阴道环境的生理状态对于宿主的健康以及成功的繁殖是重要的。高雌激素状态，如在青春期和怀孕期间所见，通过刺激阴道上皮细胞的成熟和增殖以及糖原的积累来促进阴道微环境的保持。富含糖原的阴道环境是乳酸产生和pH降低促进的乳杆菌增殖的避风港。乳杆菌及其抗微生物和抗炎产物沿着上皮粘膜屏障的组分提供了有效的第一线防御，抵抗入侵病原体，包括细菌性阴道病、需氧性阴道炎相关细菌、病毒、真菌和原生动物。最佳的宿主-微生物相互作用是维持生态良好和阴道健康所必需的。这篇综述探讨了健康状态下阴道微生物组的组成、功能和适应机制，以及宿主-微生物关系破裂的疾病状态。还概述了阴道微生态失调对生殖的潜在影响。
In addition to being a passage for sperm, menstruum, and the baby, the human vagina and its microbiota can influence conception, pregnancy, the mode and timing of delivery, and the risk of acquiring sexually transmitted infections. The physiological status of the vaginal milieu is important for the wellbeing of the host as well as for successful reproduction. High estrogen states, as seen during puberty and pregnancy, promote the preservation of a homeostatic (eubiotic) vaginal microenvironment by stimulating the maturation and proliferation of vaginal epithelial cells and the accumulation of glycogen. A glycogen-rich vaginal milieu is a haven for the proliferation of Lactobacilli facilitated by the production of lactic acid and decreased pH. Lactobacilli and their antimicrobial and anti-inflammatory products along with components of the epithelial mucosal barrier provide an effective first line defense against invading pathogens including bacterial vaginosis, aerobic vaginitis-associated bacteria, viruses, fungi and protozoa. An optimal host-microbial interaction is required for the maintenance of eubiosis and vaginal health. This review explores the composition, function and adaptive mechanisms of the vaginal microbiome in health and those disease states in which there is a breach in the host-microbial relationship. The potential impact of vaginal dysbiosis on reproduction is also outlined.
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DOI：
10.1073/pnas.1502875112
发表时间：
2015-09-01
影响因子：
11.1
作者：
DiGiulio, Daniel B.;Callahan, Benjamin J.;Relman, David A.
通讯作者：
Relman, David A.
DOI：
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发表时间：
2011-01-01
期刊：
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影响因子：
--
作者：
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通讯作者：
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影响因子：
3.4
作者：
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影响因子：
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作者：
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影响因子：
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作者：
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