A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome.
A maternal high-fat diet is accompanied by alterations in the fetal primate metabolome.
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DOI：
10.1016/j.ajog.2009.06.041
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发表时间：
2009-09
影响因子：
9.8
通讯作者：
Aagaard-Tillery, Kjersti M.
中科院分区：
文献类型：
--
作者：
Cox, James;Williams, Sarah;Grove, Kevin;Lane, Robert H.;Aagaard-Tillery, Kjersti M.
表征子宫内高脂肪暴露灵长类动物模型的血清代谢组。通过气相色谱-质谱法（GC-MS）分析暴露于高脂肪或对照饮食的母猴和胎猴（e130）的血清。进行多变量数据分析（MVDA）以减少生成的数据集。使用ANOVA和比较t检验进一步分析候选代谢物的显著性。检测到约1300个色谱特征。通过MVDA，这一数量减少到60种可能的代谢物。使用比较性t检验，22种代谢物在整个研究中具有统计学显著性（p<0.05）。仅通过母体HF饮食，胎儿表型差异伴随着7种代谢物的代谢物浓度改变（p<0.05）。子宫内高脂饮食暴露与胎儿表观基因组改变相关，并在胎儿代谢产物谱中进行特征性修饰。
To characterize the serum metabolome of a primate model of in utero high fat exposure. Serum from maternal and fetal (e130) macaques exposed to either a high fat or control diet were analyzed by gas chromatography-mass spectrometry (GC-MS). Multivariate data analysis (MVDA) was performed to reduce the generated data set. Candidate metabolites were further analyzed for significance using ANOVA and comparative t-tests. Approximately 1300 chromatographic features were detected. Through MVDA this number was reduced to 60 possible metabolites. Using comparative t-tests 22 metabolites had statistical significance (p<0.05) over the whole of the study. By virtue of maternal HF diet alone, fetal phenotypic differences are accompanied by altered metabolite concentrations of 7 metabolites (p<0.05). In utero high fat diet exposure is associated with an altered fetal epigenome and parlays a characteristic modification in the fetal metabolite profile.
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影响因子：
7.4
作者：
Jiye, A;Trygg, J;Moritz, T
通讯作者：
Moritz, T
DOI：
10.1073/pnas.0705667104
发表时间：
2007-07-31
影响因子：
11.1
作者：
Gluckman, Peter D.;Lillycrop, Karen A.;Hanson, Mark A.
通讯作者：
Hanson, Mark A.
在怀孕期间喂养蛋白质限制饮食的大鼠后代中肝糖皮质激素受体的表观遗传调节改变的诱导表明，DNA甲基转移酶-1表达降低与DNA甲基化受损和组蛋白修饰的变化有关。
影响因子：
3.6
作者：
Lillycrop, Karen A.;Slater-Jefferies, Jo L.;Hanson, Mark A.;Godfrey, Keith M.;Jackson, Alan A.;Burdge, Graham C.
通讯作者：
Burdge, Graham C.
影响因子：
6
作者：
Azzi, Angelo;Aratri, Elisabetta;Spycher, Stefan
通讯作者：
Spycher, Stefan
影响因子：
120.7
作者：
Strauss, RS;Pollack, HA
通讯作者：
Pollack, HA