Immunothrombosis in COVID-19: Implications of Neutrophil Extracellular Traps.
Immunothrombosis in COVID-19: Implications of Neutrophil Extracellular Traps.
复制标题
Covid-19中的免疫骨栓塞：中性粒细胞外陷阱的影响。
DOI：
10.3390/biom11050694
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发表时间：
2021-05-06
期刊：
影响因子：
5.5
通讯作者：
Camarena A
中科院分区：
文献类型：
--
作者：
Bautista-Becerril B;Campi-Caballero R;Sevilla-Fuentes S;Hernández-Regino LM;Hanono A;Flores-Bustamante A;González-Flores J;García-Ávila CA;Aquino-Gálvez A;Castillejos-López M;Juárez-Cisneros A;Camarena A
SARS-CoV-2是近几十年来与呼吸道疾病严重爆发相关的冠状病毒家族成员，是COVID-19大流行的病原体。先天性免疫应答的识别和激活募集中性粒细胞，中性粒细胞通过其不同的作用机制形成细胞外中性粒细胞陷阱，在感染控制和捕获病毒、细菌和真菌病原体中发挥作用。然而，在COVID-19患者中，血管水平的激活，与其他细胞和炎症介质结合，导致血栓形成事件和弥散性血管内凝血，从而导致脑血管、心脏、肺和肾脏疾病的一系列临床表现，同时促进病情严重和死亡率。先前对COVID-19住院患者的研究表明，NET特异性标志物（如游离DNA、MPO和H3Cit）水平升高与总中性粒细胞计数;与急性期反应物（包括CRP、D-二聚体、乳酸脱氢酶和白细胞介素分泌）以及严重COVID-19风险增加密切相关。本研究分析了NET与参与COVID-19患者免疫血栓形成过程的激活途径之间的相互作用。
SARS-CoV-2 is a member of the family of coronaviruses associated with severe outbreaks of respiratory diseases in recent decades and is the causative agent of the COVID-19 pandemic. The recognition by and activation of the innate immune response recruits neutrophils, which, through their different mechanisms of action, form extracellular neutrophil traps, playing a role in infection control and trapping viral, bacterial, and fungal etiological agents. However, in patients with COVID-19, activation at the vascular level, combined with other cells and inflammatory mediators, leads to thrombotic events and disseminated intravascular coagulation, thus leading to a series of clinical manifestations in cerebrovascular, cardiac, pulmonary, and kidney disease while promoting severe disease and mortality. Previous studies of hospitalized patients with COVID-19 have shown that elevated levels of markers specific for NETs, such as free DNA, MPO, and H3Cit, are strongly associated with the total neutrophil count; with acute phase reactants that include CRP, D-dimer, lactate dehydrogenase, and interleukin secretion; and with an increased risk of severe COVID-19. This study analyzed the interactions between NETs and the activation pathways involved in immunothrombotic processes in patients with COVID-19.
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DOI：
10.1016/j.ajem.2020.09.065
发表时间：
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期刊：
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影响因子：
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作者：
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影响因子：
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期刊：
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