On the sequence of A*3101.
On the sequence of A*3101.
复制标题
关于 A*3101 的序列。
DOI：
10.1111/j.1399-0039.1996.tb02580.x
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Parham,P
中科院分区：
文献类型：
--
作者：
Arnett,KL;Adams,EJ;Parham,P
A* 31等位基因的首个核苷酸序列由Kato等人(1)获得。这些作者从B细胞系JHAF的文库中分离出基因组DNA克隆。这一HLA纯合子同源细胞系（第十届国际组织相容性研讨会小组编号9030）来源于高加索人的外周血淋巴细胞，血清学特征为具有HLA- a3， b51和Cw8抗原。编码JHAF细胞系A31抗原的核苷酸序列最初被指定为A* 3101(3)。自Kato等人的报告以来，对美洲原住民的研究已经确定了编码a311（433）的等位基因的额外序列，a311是一种在许多美洲印第安人群中频率很高的抗原(6)。这些序列本身相同，但与A* 3101不同之处在于编码区核苷酸762处的T被C取代（图1）。这一替换不改变编码蛋白的氨基酸序列，因此新的A* 31序列被命名为A* 31012，原A* 3101编码序列被命名为A* 3101 1(7)。随后对美洲印第安人个体的序列分析一致显示A3抗原由A* 31012等位基因编码(8)。这一趋势提出了一种有趣的可能性，即核苷酸762处的替换将美洲衍生的a310等位基因与欧亚衍生的a310等位基因区分开来。没那么有趣，但很有趣
The first nucleotide sequence for an A* 3 1 allele was obtained by Kato et al.(1). These authors isolated a genomic DNA clone from a library made from the B cell line JHAF. This HLA homozygous, consanguineous cell line (# 9030 in the panel of the Tenth International Histocompatibility Workshop [2]) was derived from the peripheral blood lymphocytes of a Caucasoid individual and was characterized serologically as having the HLA-A3 1, B5 1 and Cw8 antigens. The nucleotide sequence encoding the A31 antigen of the JHAF cell line was initially designated as A* 3101 (3).Since the report of Kato et al., study of indigenous Americans has resulted in the determination of additional sequences for alleles encoding A3 1 (4 3, an antigen which is at high frequency in many Amerindian populations (6). These sequences, which are amongst themselves identical, differ from A* 3 101 by substitution of C for T at nucleotide 762 of the coding region (Figure 1). This substitution does not change the amino acid sequence of the encoded protein, and accordingly the novel A* 31 sequences were named A* 31012 and the original A* 3 101 encoding sequence was renamed A* 3 101 1 (7). Subsequent sequence analyses of Amerindian individuals have consistently revealed the A3 1 antigen to be encoded by the A* 31012 allele (8). An interesting possibility suggested by this trend is that the substitution at nucleotide 762 distinguishes A" 3 10 1 alleles of American derivation from those of Eurasian derivation. Less interesting, but very
登录
查看更多内容
巴西印第安人两个部落中异常的 HLA-B 等位基因
影响因子：
64.8
作者：
M. Belich;J. Madrigal;W. Hildebrand;J. Zemmour;Robert C. Williams;R. Luz;M. Petzl;P. Parham
通讯作者：
P. Parham
影响因子：
--
作者：
J. Domena;A. Little;A. Madrigal;W. Hildebrand;L. Johnston-Dow;E. D. du Toit;W. Bias;P. Parham
通讯作者：
J. Domena;A. Little;A. Madrigal;W. Hildebrand;L. Johnston-Dow;E. D. du Toit;W. Bias;P. Parham
血清学定义的 HLA-Aw19 抗原的分子分析。
DOI：
--
发表时间：
1989
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kato,K;Trapani,JA;Allopenna,J;Dupont,B;Yang,SY
通讯作者：
Yang,SY
美洲印第安人之谜。
影响因子：
--
作者：
Kostyu,DD;Amos,DB
通讯作者：
Amos,DB