Circulating metabolic signatures of heart failure in precision cardiology.
Circulating metabolic signatures of heart failure in precision cardiology.
复制标题
精密心脏病学中心力衰竭的循环代谢特征。
DOI：
10.1093/pcmedi/pbad005
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发表时间：
2023-03
影响因子：
5.3
通讯作者：
中科院分区：
文献类型：
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作者：
精准心脏病学旨在根据个人的具体特征实施个性化的医疗保健和精准的医疗决策。代谢重构在心力衰竭（HF）的发病机制中起着重要作用。代谢途径如底物选择性、高能磷酸盐代谢和氨基酸代谢的改变参与病理性结构重塑和功能损害。这些代谢改变通常不限于心脏组织，也表现在循环中。在临床实践中，血液样本常规用于HF筛查。代谢组学是一种新兴的组学技术，它提供了一种有效的方法来获得动态代谢谱循环。越来越多的代谢生物标志物与疾病进展有关，这使得以更有效和更精确的方式对抗HF成为可能。本文综述了代谢组学的现代分析技术以及HF发病过程中出现的循环代谢物，旨在为精确医学时代的HF预防，诊断和治疗提供新的见解。本文综述了代谢组学的现代分析技术以及心力衰竭发病过程中出现的循环代谢物，为精准医学时代疾病的预防、诊断和治疗提供新的见解。
Precision cardiology aims to implement personalized health care and precise medical decisions based on the specific characteristics of individuals. Metabolic remodeling plays a causal role in the pathogenesis of heart failure (HF). Changes in metabolic pathways such as substrate preference, high-energy phosphate metabolism and amino acid metabolism, are involved in pathological structural remodeling and functional impairment. These metabolic alterations are usually not restricted in the cardiac tissue, but also manifest in circulation. In clinical practice, blood sample is routinely used for HF screening. Metabolomics is an emerging omics technology that provides an efficient way to acquire dynamic metabolic profiles in circulation. An increasing number of metabolic biomarkers have been implicated in disease progression, making it possible to fight HF in a more effective and precise way. This review summarizes the modern analytical techniques in metabolomics as well as emerging circulating metabolites during the pathogenesis of HF, aiming to provide new insights into the prevention, diagnosis and treatment of HF in the era of precision medicine. This review summarizes the modern analytical techniques in metabolomics as well as emerging circulating metabolites during the pathogenesis of heart failure, to provide new insights into the prevention, diagnosis and treatment of the disease in the era of precision medicine.
影响因子：
4.1
作者：
Tremblay-Gravel M;Fortier A;Baron C;David C;Mehanna P;Ducharme A;Hussin J;Hu Q;Tardif JC;Des Rosiers C;Dupuis J;Ruiz M
通讯作者：
Ruiz M