The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids.
The Uptake and Metabolism of Amino Acids, and Their Unique Role in the Biology of Pathogenic Trypanosomatids.
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DOI：
10.3390/pathogens7020036
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发表时间：
2018-04-01
期刊：
影响因子：
--
通讯作者：
Silber AM
中科院分区：
文献类型：
--
作者：
Marchese L;Nascimento JF;Damasceno FS;Bringaud F;Michels PAM;Silber AM
布氏锥虫与克氏锥虫以及利什曼原虫属的20多种虫种共同构成了一组威胁人类健康的鞭毛虫原生生物。这些生物体通过昆虫传播，昆虫和哺乳动物是它们的天然宿主。这意味着，在其生命周期中，每一种都面临着具有不同物理、化学、生物化学和生物特性的环境。在这项工作中，我们回顾了氨基酸是如何从这样的环境中获得的，它们是如何代谢的，以及它们和它们的一些中间代谢产物是如何被用作生存工具箱，以科普不同的条件下，这些寄生虫应该建立在昆虫和哺乳动物宿主的感染。
Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus Leishmania, form a group of flagellated protists that threaten human health. These organisms are transmitted by insects that, together with mammals, are their natural hosts. This implies that during their life cycles each of them faces environments with different physical, chemical, biochemical, and biological characteristics. In this work we review how amino acids are obtained from such environments, how they are metabolized, and how they and some of their intermediate metabolites are used as a survival toolbox to cope with the different conditions in which these parasites should establish the infections in the insects and mammalian hosts.
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