High-risk Pathologic Features Based on Presenting Findings in Advanced Intraocular Retinoblastoma: A Multicenter, International Data-Sharing American Joint Committee on Cancer Study.
High-risk Pathologic Features Based on Presenting Findings in Advanced Intraocular Retinoblastoma: A Multicenter, International Data-Sharing American Joint Committee on Cancer Study.
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DOI：
10.1016/j.ophtha.2022.04.006
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发表时间：
2022-08
期刊：
影响因子：
13.7
通讯作者：
Carreras, Elisa
中科院分区：
文献类型：
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作者：
Tomar, Ankit Singh;Finger, Paul T.;Gallie, Brenda;Kivela, Tero T.;Mallipatna, Ashwin;Zhang, Chengyue;Zhao, Junyang;Wilson, Matthew W.;Brennan, Rachel C.;Burges, Michala;Kim, Jonathan;Berry, Jesse L.;Jubran, Rima;Khetan, Vikas;Ganesan, Suganeswari;Yarovoy, Andrey;Yarovaya, Vera;Kotova, Elena;Volodin, Denis;Yousef, Yacoub A.;Nummi, Kalle;Ushakova, Tatiana L.;Yugay, Olga, V;Polyakov, Vladimir G.;Ramirez-Ortiz, Marco A.;Esparza-Aguiar, Elizabeth;Chantada, Guillermo;Schaiquevich, Paula;Fandino, Adriana;Yam, Jason C.;Lau, Winnie W.;Lam, Carol P.;Sharwood, Phillipa;Moorthy, Sonia;Long, Quah Boon;Essuman, Vera Adobea;Renner, Lorna A.;Semenova, Ekaterina;Catala-Mora, Jaume;Correa-Llano, Genoveva;Carreras, Elisa
目的：确定第八版美国癌症联合委员会(AJCC)ct3分类和AJCC眼科肿瘤工作组(OOTF)确定的晚期眼内视网膜母细胞瘤的临床特征对预测高危病理特征的价值。国际、多中心、基于登记册的追溯性病例系列。来自6大洲13个国家的18个眼科肿瘤中心对942只眼进行了评估，作为AJCC ct3和ct2视网膜母细胞瘤的主要治疗方法。国际的、多中心的、基于登记的数据来自2001至2013年间登记的患者。高危病理特征定义为AJCC类型PT3和PT4。此外，AJCC OOTF大小分组如下：(1)小于一半；(2)大于一半但小于三分之二；(3)累及超过三分之二的眼球体积；(4)弥漫性浸润性视网膜母细胞瘤。AJCC ct3亚类和AJCC OOTF大小分组对应的高危病理特征的统计风险。在942只视网膜母细胞瘤患者中，282只眼(30%)表现出高危病理特征。CT亚型和AJCC OOTF大小分组(P<；均为0.001)均与高危病理特征相关。Logistic回归分析显示，cT3c(虹膜新生血管伴青光眼)、cT3d(眼内出血)和cT3e(无菌性眼眶蜂窝织炎)是高危病变的预测因素，与cT2a相比，优势比分别为2.3%(P=0.002)、2.5%(P=0.002)和3.3%(P=0.019)。与大小1组(占眼球体积的50%)相比，大小3组(超过三分之二的球体体积)和4组(弥漫性浸润性视网膜母细胞瘤)是高危病理特征的最佳预测因素，其优势比分别为3.3和4.1(P<；0.001)。AJCC视网膜母细胞瘤临床分期cT3c-e亚类(分别为青光眼、眼内出血和无菌性眼眶蜂窝织炎)以及AJCC OTF大小分组3(肿瘤超过全球体积的三分之二)和4(弥漫性浸润性视网膜母细胞瘤)都允许对临床危险因素进行分层，可用于预测高危病理特征的存在，从而有助于治疗决策。
To determine the value of clinical features for advanced intraocular retinoblastoma as defined by the eighth edition of the American Joint Committee on Cancer (AJCC) cT3 category and AJCC Ophthalmic Oncology Task Force (OOTF) Size Groups to predict the high-risk pathologic features. International, multicenter, registry-based retrospective case series. Eighteen ophthalmic oncology centers from 13 countries over 6 continents shared evaluations of 942 eyes enucleated as primary treatment for AJCC cT3 and, for comparison, cT2 retinoblastoma. International, multicenter, registry-based data were pooled from patients enrolled between 2001 and 2013. High-risk pathologic features were defined as AJCC categories pT3 and pT4. In addition, AJCC OOTF Size Groups were defined as follows: (1) less than half, (2) more than half but less than two thirds, (3) more than two thirds of globe volume involved, and (4) diffuse infiltrating retinoblastoma. Statistical risk of high-risk pathologic features corresponding to AJCC cT3 subcategories and AJCC OOTF Size Groups. Of 942 retinoblastoma eyes treated by primary enucleation, 282 (30%) showed high-risk pathologic features. Both cT subcategories and AJCC OOTF Size Groups (P < 0.001 for both) were associated with high-risk pathologic features. On logistic regression analysis, cT3c (iris neovascularization with glaucoma), cT3d (intraocular hemorrhage), and cT3e (aseptic orbital cellulitis) were predictive factors for high-risk pathologic features when compared with cT2a with an odds ratio of 2.3 (P = 0.002), 2.5 (P = 0.002), and 3.3 (P = 0.019), respectively. Size Group 3 (more than two-thirds globe volume) and 4 (diffuse infiltrative retinoblastoma) were the best predictive factors with an odds ratio of 3.3 and 4.1 (P < 0.001 for both), respectively, for high-risk pathologic features when compared with Size Groups 1 (i.e., < 50% of globe volume). The AJCC retinoblastoma staging clinical cT3c–e subcategories (glaucoma, intraocular hemorrhage, and aseptic orbital cellulitis, respectively) as well as the AJCC OOTF Size Groups 3 (tumor more than two thirds of globe volume) and 4 (diffuse infiltrative retinoblastoma) both allowed stratification of clinical risk factors that can be used to predict the presence of high-risk pathologic features and thus facilitate treatment decisions.
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影响因子：
13.7
作者：
Kletke, Stephanie N.;Feng, Zhao Xun;Soliman, Sameh E.
通讯作者：
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影响因子：
13.7
作者：
Shields, Carol L.;Mashayekhi, Arman;Shields, Jerry A.
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Shields, Jerry A.
影响因子：
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作者：
Kim, Jonathan W
通讯作者：
Kim, Jonathan W
影响因子：
3.2
作者：
Kashyap, Seema;Meel, Rachna;Ghose, Supriyo
通讯作者：
Ghose, Supriyo
DOI：
10.1097/mph.0000000000002144
发表时间：
2021-08-01
期刊：
Journal of pediatric hematology/oncology
影响因子：
--
作者：
Yousef YA;Mohammad M;Mehyar M;Sultan I;Al-Hussaini M;Alhourani J;Halalsheh H;Khzouz J;Jaradat I;Qaddoumi I;Al-Nawaiseh I
通讯作者：
Al-Nawaiseh I