What is known and unknown about chemotherapy-related cognitive impairment in patients with haematological malignancies and areas of needed research.
What is known and unknown about chemotherapy-related cognitive impairment in patients with haematological malignancies and areas of needed research.
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DOI：
10.1111/bjh.14211
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发表时间：
2016-09
影响因子：
6.5
通讯作者：
Janelsins MC
中科院分区：
文献类型：
--
作者：
Williams AM;Zent CS;Janelsins MC
Cancer-related cognitive impairment (CRCI) is an important clinical problem for cancer patients and survivors. In this review, we summarize studies investigating the occurrence of impaired cognition in patients with haematological malignancies. Most published studies focus on survivors of childhood acute lymphoblastic leukaemia and primary CNS lymphoma. We also discuss studies conducted in acute myeloid leukaemia, myelodysplastic syndromes, chronic myeloid leukaemia, Hodgkin lymphoma, non-Hodgkin lymphoma and chronic lymphocytic leukaemia. Although research in this area is still emerging, it appears that a subset of chemotherapy-treated haematological malignancy survivors experience CRCI. Future research should focus on expanding the literature reviewed here with larger studies appropriately powered to assess cognition via objective and subjective measures in a longitudinal fashion to tease apart the impact of disease and the various forms of cancer treatment.
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