One-Year Effects of Omega-3 Treatment on Fatty Acids, Oxylipins, and Related Bioactive Lipids and Their Associations with Clinical Lipid and Inflammatory Biomarkers: Findings from a Substudy of the Vitamin D and Omega-3 Trial (VITAL).
One-Year Effects of Omega-3 Treatment on Fatty Acids, Oxylipins, and Related Bioactive Lipids and Their Associations with Clinical Lipid and Inflammatory Biomarkers: Findings from a Substudy of the Vitamin D and Omega-3 Trial (VITAL).
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DOI：
10.3390/metabo10110431
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发表时间：
2020-10-27
期刊：
影响因子：
4.1
通讯作者：
Mora S
中科院分区：
文献类型：
--
作者：
Demler OV;Liu Y;Luttmann-Gibson H;Watrous JD;Lagerborg KA;Dashti H;Giulianini F;Heath M;Camargo CA Jr;Harris WS;Wohlgemuth JG;Andres AM;Tivari S;Long T;Najhawan M;Dao K;Prentice JG;Larsen JA;Okereke OI;Costenbader KH;Buring JE;Manson JE;Cheng S;Jain M;Mora S
Omega-3 （n-3）治疗可能降低心血管风险，但其对循环脂质组的影响及其与心血管风险生物标志物的关系尚不清楚。我们假设n-3治疗与下游脂肪酸（FAs）、氧化脂质、生物活性脂质、临床脂质和炎症生物标志物的有利变化有关。我们检查了这些VITAL200，这是一个嵌套的子研究，200名受试者在人口统计学和治疗方面保持平衡，并从维生素D和Omega-3试验（VITAL）中随机选择。VITAL是一项随机双盲试验，在25,871名受试者中使用840毫克/天的二十碳五烯酸(EPA) +二十二碳六烯酸（DHA）与安慰剂。在基线和一年时，使用三种独立的分析技术测量血浆和红细胞的小极性生物活性脂质特征、氧脂素和FAs。妇女健康研究（WHS）用于重复饮食中n-3的摄入。随机n-3处理导致WHS中143种FAs、氧化脂类和生物活性脂类发生变化（VITAL200中错误发现率（False Discovery Rate， FDR） < 0.05，验证值（p值< 0.05）），其中95种增加，包括EPA、DHA、n-3二十二碳五烯酸（DPA-n3）， 48种减少，包括DPA-n6、二homo γ亚麻酸（DGLA）、肾上腺素和花生四烯酸。生物活性脂质组中N-3相关的变化与临床脂质和炎症生物标志物的变化呈异质性相关。N-3治疗可显著调节生物活性脂质组，这可能有助于其临床益处。
Omega-3 (n-3) treatment may lower cardiovascular risk, yet its effects on the circulating lipidome and relation to cardiovascular risk biomarkers are unclear. We hypothesized that n-3 treatment is associated with favorable changes in downstream fatty acids (FAs), oxylipins, bioactive lipids, clinical lipid and inflammatory biomarkers. We examined these VITAL200, a nested substudy of 200 subjects balanced on demographics and treatment and randomly selected from the Vitamin D and Omega-3 Trial (VITAL). VITAL is a randomized double-blind trial of 840 mg/d eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) vs. placebo among 25,871 individuals. Small polar bioactive lipid features, oxylipins and FAs from plasma and red blood cells were measured using three independent assaying techniques at baseline and one year. The Women’s Health Study (WHS) was used for replication with dietary n-3 intake. Randomized n-3 treatment led to changes in 143 FAs, oxylipins and bioactive lipids (False Discovery Rate (FDR) < 0.05 in VITAL200, validated (p-values < 0.05)) in WHS with increases in 95 including EPA, DHA, n-3 docosapentaenoic acid (DPA-n3), and decreases in 48 including DPA-n6, dihomo gamma linolenic (DGLA), adrenic and arachidonic acids. N-3 related changes in the bioactive lipidome were heterogeneously associated with changes in clinical lipid and inflammatory biomarkers. N-3 treatment significantly modulates the bioactive lipidome, which may contribute to its clinical benefits.
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海洋N-3脂肪酸和心血管疾病和癌症的预防。
DOI：
10.1056/nejmoa1811403
发表时间：
2019-01-03
期刊：
The New England journal of medicine
影响因子：
--
作者：
Manson JE;Cook NR;Lee IM;Christen W;Bassuk SS;Mora S;Gibson H;Albert CM;Gordon D;Copeland T;D'Agostino D;Friedenberg G;Ridge C;Bubes V;Giovannucci EL;Willett WC;Buring JE;VITAL Research Group
通讯作者：
VITAL Research Group
DOI：
10.1084/jem.192.8.1197
发表时间：
2000-10-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Serhan CN;Clish CB;Brannon J;Colgan SP;Chiang N;Gronert K
通讯作者：
Gronert K
影响因子：
120.7
作者：
Cook, NR;Lee, IM;Buring, JE
通讯作者：
Buring, JE
影响因子：
24
作者：
Aung T;Halsey J;Kromhout D;Gerstein HC;Marchioli R;Tavazzi L;Geleijnse JM;Rauch B;Ness A;Galan P;Chew EY;Bosch J;Collins R;Lewington S;Armitage J;Clarke R;Omega-3 Treatment Trialists’ Collaboration
通讯作者：
Omega-3 Treatment Trialists’ Collaboration
影响因子：
4.1
作者：
Henglin, Mir;Niiranen, Teemu;Cheng, Susan
通讯作者：
Cheng, Susan