Nano-layered microneedles for transcutaneous delivery of polymer nanoparticles and plasmid DNA.
Nano-layered microneedles for transcutaneous delivery of polymer nanoparticles and plasmid DNA.
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DOI：
10.1002/adma.201001525
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发表时间：
2010-11-16
影响因子：
29.4
通讯作者：
Irvine, Darrell J.
中科院分区：
文献类型：
--
作者：
DeMuth, Peter C.;Su, Xingfang;Samuel, Raymond E.;Hammond, Paula T.;Irvine, Darrell J.
目前的疫苗和治疗给药主要是基于针头的，[1]但针头给药的一些固有风险和缺点已被认识到，例如需要冷藏液体制剂，[1，2]需要训练有素的人员进行给药，以及由于针头重复使用和针头损伤而降低安全性。[3]为了解决这些限制，通过皮肤接种疫苗和治疗药物是一种很有前途的替代策略，[4-6]促进各种药物和疫苗的有效经皮递送的技术已成为最近研究的一个重要焦点(见[7])。这一领域的最新研究表明，微针阵列可有效和无痛地破坏角质层，促进各种生物活性物质的经皮给药。[8，9]微针给药通常是通过将干燥的水溶性药物直接涂覆在固体微针的表面实现的。在聚电解质多层(PEM)工程领域的平行研究表明，将简单和通用的材料封装到共形薄膜中的潜力，提供了对材料释放的强有力控制，对环境敏感的封装材料的固态稳定，以及纳米...
Current vaccine and therapeutic delivery is largely needle-based,[1] but a number of inherent risks and disadvantages to needle-based delivery have been recognized, such as the need for cold storage of liquid formulations,[1, 2] the requirement of trained personnel for administration, and reduced safety due to needle re-use and needle-based injuries.[3] To address these limitations, vaccination and therapeutics administration through the skin represents a promising alternative strategy,[4-6] and technologies promoting efficient transcutaneous delivery of a variety of drugs and vaccines has become a significant focus of recent research (reviewed in [7]). Recent work in this area has demonstrated the utility of microneedle arrays for efficient and pain-free disruption of the stratum corneum (SC), promoting transcutaneous delivery of a variety of bio-active materials.[8, 9] Microneedle delivery is often achieved by coating dried water-soluble drug formulations directly on the surfaces of solid microneedles. Parallel studies in the area of polyelectrolyte multilayer (PEM) engineering have demonstrated the potential for simple and versatile materials encapsulation into conformal thin films, providing robust control over materials release, solid-state stabilization of environmentally-sensitive encapsulated materials, and nanometer-
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DOI：
10.1086/649228
发表时间：
2010-01-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Kim YC;Quan FS;Yoo DG;Compans RW;Kang SM;Prausnitz MR
通讯作者：
Prausnitz MR
DOI：
10.1073/pnas.0508246103
发表时间：
2006-06-06
影响因子：
11.1
作者：
Jessel, N;Oulad-Abdeighani, M;Voegel, JC
通讯作者：
Voegel, JC
影响因子：
10.8
作者：
Park, JH;Allen, MG;Prausnitz, MR
通讯作者：
Prausnitz, MR
影响因子：
2.8
作者：
Haq, M. I.;Smith, E.;Birchall, J. C.
通讯作者：
Birchall, J. C.
影响因子：
12.4
作者：
Greenland, JR;Liu, HN;Letvin, NL
通讯作者：
Letvin, NL