Locus coeruleus activation facilitates memory encoding and induces hippocampal LTD that depends on beta-adrenergic receptor activation.
Locus coeruleus activation facilitates memory encoding and induces hippocampal LTD that depends on beta-adrenergic receptor activation.
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DOI：
10.1093/cercor/bhp065
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发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
Manahan-Vaughan D
中科院分区：
文献类型：
--
作者：
Lemon N;Aydin-Abidin S;Funke K;Manahan-Vaughan D
空间记忆的形成是通过突触信息处理实现的，其形式是海马内突触的持续加强和减弱。然而，不清楚如何选择相关的空间信息进行编码，而不是不太相关的信息。由于去甲肾上腺素能蓝斑（LC）变得活跃，以应对新的经验，我们假设，LC可能提供的显着性信号，促进海马编码的相关信息，通过突触强度的变化。在行为自由的成年大鼠中，测试脉冲刺激在谢弗侧支（SC）-CA 1放射层突触诱发稳定的基础突触传递。这些测试脉冲与LC的电刺激的耦合在SC-CA 1突触处诱导长期抑制（LTD），并诱导θ频率振荡的瞬时抑制。作用是N-甲基-D-天冬氨酸和β-肾上腺素能受体依赖性的。LC的激活也增加了CA 1去甲肾上腺素水平，并通过β-肾上腺素受体依赖性机制促进了单次发作的空间记忆的编码。我们的研究结果表明，LC在诱导海马LTD和促进空间信息的编码中起着关键作用。这种LC-海马的相互作用可能反映了一种方法，通过这种方法，显著的信息被区分为随后的突触处理。
Spatial memory formation is enabled through synaptic information processing, in the form of persistent strengthening and weakening of synapses, within the hippocampus. It is, however, unclear how relevant spatial information is selected for encoding, in preference to less pertinent information. As the noradrenergic locus coeruleus (LC) becomes active in response to novel experiences, we hypothesized that the LC may provide the saliency signal required to promote hippocampal encoding of relevant information through changes in synaptic strength. Test pulse stimulation evoked stable basal synaptic transmission at Schaffer collateral (SC)–CA1 stratum radiatum synapses in freely behaving adult rats. Coupling of these test pulses with electrical stimulation of the LC induced long-term depression (LTD) at SC–CA1 synapses and induced a transient suppression of theta-frequency oscillations. Effects were N-methyl-D-aspartate and β-adrenergic receptor dependent. Activation of the LC also increased CA1 noradrenalin levels and facilitated the encoding of spatial memory for a single episode via a β-adrenoceptor–dependent mechanism. Our results demonstrate that the LC plays a key role in the induction of hippocampal LTD and in promoting the encoding of spatial information. This LC–hippocampal interaction may reflect a means by which salient information is distinguished for subsequent synaptic processing.
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影响因子：
5.3
作者：
Ergorul, C;Eichenbaum, H
通讯作者：
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影响因子：
2
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16.2
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3.5
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2.5
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