The Release of Norepinephrine in C57BL/6J Mice Treated with 6-Hydroxydopamine (6-OHDA) is Associated with Translocations in Enteric Escherichia coli via the QseC Histidine Kinase Receptor
The Release of Norepinephrine in C57BL/6J Mice Treated with 6-Hydroxydopamine (6-OHDA) is Associated with Translocations in Enteric Escherichia coli via the QseC Histidine Kinase Receptor
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经 6-羟基多巴胺 (6-OHDA) 处理的 C57BL/6J 小鼠中去甲肾上腺素的释放与肠道大肠杆菌中通过 QseC 组氨酸激酶受体的易位相关
DOI：
10.12659/msm.922986
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发表时间：
2020-06
影响因子：
3.1
通讯作者：
Yang Kun
中科院分区：
文献类型：
--
作者：
Meng Jun;Chen Huamei;Lv Qin;Luo Xiaodan;Yang Kun
目的：研究内源性储备释放的去甲肾上腺素（NE）对选择性破坏去甲肾上腺素能神经末梢的6-羟基多巴胺（6-OHDA）诱导的小鼠大肠杆菌细菌移位的影响。材料/方法E.以大肠杆菌菌株BW 25113及其衍生物（BW 25113 ΔqseC和BW 25113 ΔqseC pQseC）为研究对象。分析血清内毒素浓度。从6-OHDA处理的小鼠采集的组织标本中分别检测到菌株BW 25113、BW 25113 ΔqseC和BW 25113 ΔqseC pQseC。结果与BW 25113处理的小鼠相比，BW 25113 ΔqseC处理的小鼠在施用6-OHDA后显示出降低的细菌易位水平。E.大肠杆菌QseC受体使去甲肾上腺素-QseC信号链中断，细菌对肠粘膜的侵袭力和穿透力减弱，最终导致细菌易位发生率显著降低。结论NE通过QseC调控肠道致病菌与宿主的相互作用。阻断QseC受体介导的作用可能有助于减弱细菌易位。
Background We aimed to investigate the effects of norepinephrine (NE) released from endogenous stores on bacterial translocation of Escherichia coli in mice by administration of 6-hydroxydopamine (6-OHDA), which selectively destroys noradrenergic nerve terminals. Material/Methods E. coli strain BW25113 and its derivatives (BW25113ΔqseC and BW25113ΔqseC pQseC) were used in this study. The serum concentrations of endotoxin were analyzed. The strains BW25113, BW25113ΔqseC, and BW25113ΔqseC pQseC were detected respectively in tissue specimens harvested from mice treated with 6-OHDA. Results Mice treated with BW25113ΔqseC showed reduced levels of bacterial translocation following administration of 6-OHDA compared with mice treated with BW25113. The defect of E. coli QseC receptor caused the norepinephrine-QseC signal chain to be interrupted, and the invasiveness and penetrating power of the bacteria on the intestinal mucosa was weakened, eventually leading to a significant decrease in the incidence of bacterial translocation. Conclusions NE modulates the interaction of enteric bacterial pathogens with their hosts via QseC. The blockade of the QseC receptor-mediated effects may be useful to attenuate bacterial translocation.
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影响因子：
5.4
作者：
Carlson-Banning KM;Sperandio V
通讯作者：
Sperandio V
影响因子：
2.1
作者：
Feng, Xiao-Yan;Yan, Jing-Ting;Zhu, Jin-Xia
通讯作者：
Zhu, Jin-Xia
影响因子：
25.7
作者：
Sorribas, Marcel;Jakob, Manuel O.;Wiest, Reiner
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Wiest, Reiner
影响因子：
3.2
作者：
Halang, Petra;Toulouse, Charlotte;Steuber, Julia
通讯作者：
Steuber, Julia
肠道微生物群通过海马体中的糖皮质激素受体途径基因调节小鼠行为。
影响因子：
6.8
作者：
Luo Y;Zeng B;Zeng L;Du X;Li B;Huo R;Liu L;Wang H;Dong M;Pan J;Zheng P;Zhou C;Wei H;Xie P
通讯作者：
Xie P