Enterohemorrhagic Escherichia coli outwits hosts through sensing small molecules.

Enterohemorrhagic Escherichia coli outwits hosts through sensing small molecules.
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DOI:
10.1016/j.mib.2017.12.002
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发表时间:
2018-03
影响因子:
5.4
通讯作者:
Sperandio V
Sperandio V
中科院分区:
生物学2区
文献类型:
--
作者:
Carlson-Banning KM;Sperandio V

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Small molecules help intestinal pathogens navigate the complex human gastrointestinal tract to exploit favorable microhabitats. These small molecules provide spatial landmarks for pathogens to regulate synthesis of virulence caches and are derived from the host, ingested plant and animal material, and the microbiota. Their concentrations and fluxes vary along the length of the gut and provide molecular signatures that are beginning to be explored through metabolomics and genetics. However, while many small molecules have been identified and are reviewed here, there are undoubtedly others that may also profoundly affect how enteric pathogens infect their hosts.
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