Atorvastatin inhibits the expression of RAGE induced by advanced glycation end products on aortas in healthy Sprague-Dawley rats.
Atorvastatin inhibits the expression of RAGE induced by advanced glycation end products on aortas in healthy Sprague-Dawley rats.
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阿托伐他汀抑制健康 Sprague-Dawley 大鼠主动脉上晚期糖基化终末产物诱导的 RAGE 表达
DOI：
10.1186/1758-5996-6-102
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发表时间：
2014
影响因子：
4.8
通讯作者：
Qian Q
中科院分区：
文献类型：
--
作者：
Xu L;Zang P;Feng B;Qian Q
研究背景阿托伐他汀可下调糖尿病大鼠胰岛糖基化终末产物受体（receptor for advanced glycation end products，RECEPTOR）的表达。然而，它对健康大鼠的影响尚不清楚。本研究的目的是观察阿托伐他汀对晚期糖基化终产物（AGEs）诱导的健康Sprague道利（SD）rates.MethodsSD大鼠AGE-BSA（20 mg/kg/day或40 mg/kg/day）、双重治疗（AGE-BSA 40 mg/kg/day和阿托伐他汀20 mg/kg/day）或不治疗的直接影响，分别进行12周和24周。通过定量RT-PCR、免疫组化和western-blot检测AGEs在动物睾丸中的沉积和AGEs的表达。结果AGE-BSA以时间和剂量依赖性方式上调血清AGEs水平、AGEs沉积和动脉粥样硬化中AGEs的表达，加速动脉粥样硬化的发生和发展。这些上调可以显着衰减阿托伐他汀在其降脂作用的情况下。结论阿托伐他汀对健康SD大鼠AGEs-β表达有直接的抑制作用。这些潜在的多效性血管保护作用与血糖和血脂控制无关。
BackgroundAtorvastatin can downregulate the expression of receptor for advanced glycation end products (RAGE) in the aortas of diabetic rats. However, its effect on healthy rats remains unclear. The aim of this study was to observe the direct impact of atorvastatin on advanced glycation end products- (AGEs) induced RAGE expression in healthy Sprague Dawley (SD) rats.MethodsSD rats received AGE-BSA (20 mg/kg/day or 40 mg/kg/day), dual treatment (AGE-BSA 40 mg/kg/day and atorvastatin 20 mg/kg/day) or no treatment for 12 and 24 weeks, respectively. The deposition of AGEs and expression of RAGE in the animals’ aortas were assessed by Quantitative RT-PCR, immunohistochemistry, and western-blot tests. Serum levels of AGEs were measured using ELISA.ResultsAGE-BSA upregulated the serum level of AGEs, deposition of AGEs, and expression of RAGE in aortas in a time- and dose-dependent way that can accelerate the development and progression of atherosclerosis. These upregulations could be significantly attenuated by atorvastatin in the absence of its lipid-lowering effects. These data provide further evidence for the novo mechanism of atorvastatin’s pleiotropic effect.ConclusionAtorvastatin has a direct inhibitory effect on AGEs-RAGE expression in healthy SD rats. These potential pleiotropic vasculoprotective effects are independent of effects on glucose and lipid control.
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影响因子：
2.6
作者：
de la Maza, Maria Pia;Uribarri, Jaime;Bunout, Daniel
通讯作者：
Bunout, Daniel
影响因子：
37.8
作者：
Cipollone, F;Iezzi, A;Mezzetti, A
通讯作者：
Mezzetti, A
影响因子：
4.8
作者：
Huttunen, HJ;Fages, C;Rauvala, H
通讯作者：
Rauvala, H
影响因子：
16.2
作者：
Keech, A;Colquhoun, D;Tonkin, A
通讯作者：
Tonkin, A
影响因子：
5.3
作者：
Aviram, M;Rosenblat, M;Newton, RS
通讯作者：
Newton, RS