Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia.
Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia.
复制标题
DOI：
10.1038/ng.763
复制
发表时间：
2011-03
期刊：
影响因子：
30.8
通讯作者：
Relling, Mary V.
中科院分区：
文献类型：
--
作者：
Yang, Jun J.;Cheng, Cheng;Devidas, Meenakshi;Cao, Xueyuan;Fan, Yiping;Campana, Dario;Yang, Wenjian;Neale, Geoff;Cox, Nancy J.;Scheet, Paul;Borowitz, Michael J.;Winick, Naomi J.;Martin, Paul L.;Willman, Cheryl L.;Bowman, W. Paul;Camitta, Bruce M.;Carroll, Andrew;Reaman, Gregory H.;Carroll, William L.;Loh, Mignon;Hunger, Stephen P.;Pui, Ching-Hon;Evans, William E.;Relling, Mary V.
虽然在大多数工业化国家，儿童急性淋巴细胞白血病（ALL）的五年存活率现在超过80%，但并非所有儿童都能从这一进步中平等受益。在许多临床研究中报告了儿童ALL后生存率的种族差异，与欧洲裔美国人或亚洲人相比，非洲裔美国人或西班牙裔美国人的生存率较差，。种族差异的原因仍然不确定，尽管遗传和非遗传因素可能都很重要。在一个庞大的ALL儿童队列中，通过询问全基因组种系SNP基因型，我们观察到与美洲原住民血统共分离的基因组变异成分与复发风险相关（P= 0.0029），即使在调整已知的预后因素（P= 0.017）后。通过增加一个额外的化疗期，消除了与祖先相关的复发风险差异，表明治疗的修改可以减轻与祖先相关的复发风险。
Although five-year survival rates for childhood acute lymphoblastic leukemia (ALL) are now over 80% in most industrialized countries, not all children have benefited equally from this progress. Ethnic differences in survival after childhood ALL have been reported in many clinical studies,,,,,,,,, with poorer survival observed among African Americans or those with Hispanic ethnicity when compared with European Americans or Asians,,. The causes of ethnic differences remain uncertain, although both genetic and non-genetic factors are likely important,. Interrogating genome-wide germline SNP genotypes in an unselected large cohort of children with ALL, we observed that the component of genomic variation that co-segregated with Native American ancestry was associated with risk of relapse (P= 0.0029) even after adjusting for known prognostic factors (P= 0.017). Ancestry-related differences in relapse risk were abrogated by the addition of a single extra phase of chemotherapy, indicating that modifications to therapy can mitigate the ancestry-related risk of relapse.
登录
查看更多内容
影响因子：
9.8
作者：
Mao, Xianyun;Bigham, Abigail W.;Parra, Esteban J.
通讯作者：
Parra, Esteban J.
影响因子：
20.3
作者：
Coustan-Smith, E;Sancho, J;Campana, D
通讯作者：
Campana, D
影响因子：
120.7
作者：
PUI, CH;BOYETT, JM;CRIST, WM
通讯作者：
CRIST, WM
影响因子：
20.3
作者：
Borowitz, Michael J.;Devidas, Meenakshi;Camitta, Bruce M.
通讯作者：
Camitta, Bruce M.
影响因子：
9.8
作者：
Sankararaman, Sriram;Sridhar, Srinath;Halperin, Eran
通讯作者：
Halperin, Eran