Secreted molecules in metanephric induction.
Secreted molecules in metanephric induction.
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后肾诱导中的分泌分子。
DOI：
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发表时间：
2000
影响因子：
13.6
通讯作者：
A. McMahon
中科院分区：
文献类型：
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作者：
T. Carroll;A. McMahon
近50岁以前，Clifford Grobstein观察到输尿管芽诱导肾间质进行小管发生。自从那次发现以来，科学家们一直试图描述诱导剂的分子性质。到目前为止，还没有一个单一的分子，这是必要的和足够的肾诱导已被确定。由于最近的见解关于几个分泌分子在肾小管发生中的作用，它已成为必要的修改后肾诱导的经典模型。迄今为止，对经典输尿管诱导剂的研究很可能是对间充质特异性诱导剂Wnt-4及其在肾小管发生中的作用的表征。输尿管诱导很可能涉及一系列不同的事件，这些事件向间充质提供增殖、存活和冷凝信号，将输尿管系统的生长与小管发生整合。
Nearly 50 yr. ago, Clifford Grobstein made the observation that the ureteric bud induced the nephrogenic mesenchyme to undergo tubulogenesis. Since that discovery, scientists have attempted to characterize the molecular nature of the inducer. To date, no single molecule that is both necessary and sufficient for nephric induction has been identified. Because of recent insights regarding the role of several secreted molecules in tubulogenesis, it has become necessary to revise the classic model of metanephric induction. The studies of the classic ureteric inducer performed to date have most likely been characterizations of a mesenchyme-specific inducer, Wnt-4, and its role in tubulogenesis. Ureteric induction most likely involves a series of distinct events that provide proliferative, survival, and condensation signals to the mesenchyme, integrating the growth of the ureteric system with tubulogenesis.
DOI：
10.1152/ajprenal.1997.273.5.f757
发表时间：
1997-11-01
影响因子：
4.2
作者：
Barasch, J;Qiao, JZ;Herzlinger, D
通讯作者：
Herzlinger, D