DDA1, a novel oncogene, promotes lung cancer progression through regulation of cell cycle.
DDA1, a novel oncogene, promotes lung cancer progression through regulation of cell cycle.
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DDA1是一种新型癌基因，通过调节细胞周期促进肺癌进展
DOI：
10.1111/jcmm.13084
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发表时间：
2017-08
影响因子：
5.3
通讯作者：
Deng H
中科院分区：
文献类型：
--
作者：
Cheng L;Yang Q;Li C;Dai L;Yang Y;Wang Q;Ding Y;Zhang J;Liu L;Zhang S;Fan P;Hu X;Xiang R;Yu D;Wei Y;Deng H
肺癌在全球范围内广泛分布，并且与高发病率和死亡率相关。DDA 1（DET 1 and DDB 1 associated 1）是我们的同事首次发现并在GenBank数据库中注册的。DDA 1是一个进化上保守的基因，可能具有重要的功能。最近的研究表明，DDA 1与泛素-蛋白酶体途径有关，并促进靶蛋白的降解。然而，DDA 1在肺癌中的功能以前是未知的。本研究旨在探讨DDA 1是否参与肺癌的发生和发展。我们发现，DDA 1在正常肺细胞和组织中的表达明显低于肺癌，并与预后不良有关。DDA 1过表达促进肺肿瘤细胞增殖，并促进体外细胞周期进展和体内皮下异种移植肿瘤进展。从机制上讲，这与S期和细胞周期蛋白（包括细胞周期蛋白D1/D3/E1）的调节有关。这些结果表明，DDA 1促进肺癌进展，可能通过促进细胞周期蛋白和细胞周期进程。因此，DDA 1有可能成为肺癌治疗的新靶点和肿瘤预后的生物标志物。
Lung cancer is globally widespread and associated with high morbidity and mortality. DDA1 (DET1 and DDB1 associated 1) was first discovered and registered in the GenBank database by our colleagues. DDA1, an evolutionarily conserved gene, might have significant functions. Recent reports have demonstrated that DDA1 is linked to the ubiquitin–proteasome pathway and facilitates the degradation of target proteins. However, the function of DDA1 in lung cancer was previously unknown. This study aimed to investigate whether DDA1 contributes to tumorigenesis and progression of lung cancer. We found that the expression of DDA1 in normal lung cells and tissue was significantly lower than that in lung cancer and was associated with poor prognosis. DDA1 overexpression promoted proliferation of lung tumour cells and facilitated cell cycle progression in vitro and subcutaneous xenograft tumour progression in vivo. Mechanistically, this was associated with the regulation of S phase and cyclins including cyclin D1/D3/E1. These results indicate that DDA1 promotes lung cancer progression, potentially through promoting cyclins and cell cycle progression. Therefore, DDA1 may be a potential novel target for lung cancer treatment, and a biomarker for tumour prognosis.
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影响因子：
16
作者：
Aregger M;Kaskar A;Varshney D;Fernandez-Sanchez ME;Inesta-Vaquera FA;Weidlich S;Cowling VH
通讯作者：
Cowling VH
影响因子：
4.3
作者：
Cooley, Anne;Zelivianski, Stanislav;Jeruss, Jacqueline S.
通讯作者：
Jeruss, Jacqueline S.
影响因子：
7.3
作者：
Koutsami, M. K.;Tsantoulis, P. K.;Gorgoulis, V. G.
通讯作者：
Gorgoulis, V. G.
影响因子：
50.3
作者：
Choi YJ;Li X;Hydbring P;Sanda T;Stefano J;Christie AL;Signoretti S;Look AT;Kung AL;von Boehmer H;Sicinski P
通讯作者：
Sicinski P
影响因子：
13.8
作者：
Jackson, Sarah;Xiong, Yue
通讯作者：
Xiong, Yue