Gynecologic cancer disparities: a report from the Health Disparities Taskforce of the Society of Gynecologic Oncology.

Gynecologic cancer disparities: a report from the Health Disparities Taskforce of the Society of Gynecologic Oncology.
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DOI:
10.1016/j.ygyno.2013.12.039
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发表时间:
2014-05
影响因子:
4.7
通讯作者:
Farley JH
Farley JH
中科院分区:
医学2区
文献类型:
--
作者:
Collins Y;Holcomb K;Chapman-Davis E;Khabele D;Farley JH

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审查妇科癌症护理和结果方面的健康差异程度,并提出帮助抵消这些差异的建议。我们检索了电子数据库 PubMed 和 Cochrane 图书馆。我们纳入的研究表明,美国 (US) 妇科癌症的发病率、治疗和生存率存在可量化的种族和民族差异。大多数研究依赖于回顾性数据。由于针对非黑人女性的研究数量有限,我们关注黑人和白人女性之间的差异。与黑人女性相比,白人女性患卵巢癌的几率更高。然而,黑人女性的全因卵巢癌死亡率是白人女性的1.3倍。黑人女性的子宫内膜癌和宫颈癌死亡率是白人女性的两倍。这些差异的原因是多方面的。然而,许多证据表明,平等的护理会给被诊断患有妇科癌症的黑人女性带来平等的结果。潜在的分子因素可能在侵袭性肿瘤生物学和子宫内膜癌的差异中发挥额外作用。黑人和白人女性之间存在妇科癌症差异。由于缺乏大型前瞻性试验和足够数量的非黑人种族和族裔群体,文献受到限制。最后,我们建议继续研究和采取多方面的方法来消除妇科癌症差异。
To review the extent of health disparities in gynecologic cancer care and outcomes and to propose recommendations to help counteract the disparities. We searched the electronic databases PubMed and the Cochrane Library. We included studies demonstrating quantifiable differences by race and ethnicity in the incidence, treatment, and survival of gynecologic cancers in the United States (US). Most studies relied on retrospective data. We focused on differences between Black and White women, because of the limited number of studies on non-Black women. White women have a higher incidence of ovarian cancer compared to Black women. However, the all-cause ovarian cancer mortality in Black women is 1.3 times higher than that of White women. Endometrial and cervical cancer mortality in Black women is twice that of White women. The etiology of these disparities is multifaceted. However, much of the evidence suggests that equal care leads to equal outcomes for Black women diagnosed with gynecologic cancers. Underlying molecular factors may play an additional role in aggressive tumor biology and endometrial cancer disparities. Gynecologic cancer disparities exist between Black and White women. The literature is limited by the lack of large prospective trials and adequate numbers of non-Black racial and ethnic groups. We conclude with recommendations for continued research and a multifaceted approach to eliminate gynecologic cancer disparities.
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