The role of microRNAs in liver cancer progression.
The role of microRNAs in liver cancer progression.
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DOI：
10.1038/sj.bjc.6606010
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发表时间：
2011-01-18
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
原发性肝癌是世界范围内最常见和侵袭性最强的恶性肿瘤之一，以肝细胞癌为主。MicroRNAs(MiRNAs)是一类在转录后调节基因表达的非编码小RNA。新的证据表明，miRNAs在肝细胞癌中经常被解除调控，并且某些特定的miRNAs与肝细胞癌的临床病理特征有关。最近的研究表明，miRNAs在肝细胞癌的发展过程中起着重要作用，并通过靶向大量的关键蛋白编码基因，直接促进细胞增殖、避免细胞凋亡和肝细胞癌的转移。异常表达的miRNAs及其相应靶点的发现为研究肝癌发生发展的分子机制和开发潜在的抗肝癌药物开辟了一条新的途径。在这篇综述中，我们总结了目前关于miRNAs在肝癌进展中的作用和有效靶点的知识。
Primary liver cancer, predominantly consisting of hepatocellular carcinoma (HCC), is one of the most common and aggressive human malignancies worldwide. MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression post-transcriptionally. Emerging evidence indicates that miRNAs are often deregulated in HCC, and that some specific miRNAs are associated with the clinicopathological features of HCC. Recent work demonstrates that miRNAs have essential roles in HCC progression and directly contribute to cell proliferation, avoidance of apoptotic cell death, and metastasis of HCC by targeting a large number of critical protein-coding genes. The discovery of the aberrantly expressed miRNAs and their corresponding targets has opened a novel avenue to investigate the molecular mechanism of HCC progression and to develop potential therapeutics against HCC. In this review, we summarise current knowledge about the roles and validated targets of miRNAs in liver cancer progression.
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