Extracellular vesicles in the retina - putative roles in physiology and disease.
Extracellular vesicles in the retina - putative roles in physiology and disease.
复制标题
视网膜中的细胞外囊泡-在生理学和疾病中的假定作用。
DOI：
10.3389/fnmol.2022.1042469
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发表时间：
2022
影响因子：
4.8
通讯作者：
Pearson, Rachael A.
中科院分区：
文献类型：
--
作者：
Kalargyrou, Aikaterini A.;Guilfoyle, Siobhan E.;Smith, Alexander J.;Ali, Robin R.;Pearson, Rachael A.
关键词：
视网膜包括神经元、神经胶质、上皮细胞和血管内皮细胞的网络，所有这些都协调视觉功能。传统上，这种组织中的分子信息交换被认为是由突触和间隙连接协调的。最近的研究结果表明，许多细胞类型能够通过细胞外囊泡（EV）包装和共享分子信息，并且这些精细纳米结构的可视化和跟踪技术进步表明EV在细胞通信中的作用是多效性的。EV在生理条件下由许多细胞释放，但它们也在各种疾病阶段释放，可能反映了其货物中细胞的健康状况。关于EV释放在视网膜中的生理作用知之甚少。然而，在损伤后体内施用外源性EV提示神经营养作用，而在视网膜变性的早期阶段的感光细胞移植，EV可能促进感光细胞和Müller胶质细胞之间的相互作用。在这篇综述中，我们考虑了EV在视网膜生理学中的一些拟议作用，并讨论了目前关于其通过基因或细胞替代策略对眼部治疗的潜在影响的证据，以及在患病眼睛中直接眼内给药。
The retina encompasses a network of neurons, glia and epithelial and vascular endothelia cells, all coordinating visual function. Traditionally, molecular information exchange in this tissue was thought to be orchestrated by synapses and gap junctions. Recent findings have revealed that many cell types are able to package and share molecular information via extracellular vesicles (EVs) and the technological advancements in visualisation and tracking of these delicate nanostructures has shown that the role of EVs in cell communication is pleiotropic. EVs are released under physiological conditions by many cells but they are also released during various disease stages, potentially reflecting the health status of the cells in their cargo. Little is known about the physiological role of EV release in the retina. However, administration of exogenous EVs in vivo after injury suggest a neurotrophic role, whilst photoreceptor transplantation in early stages of retina degeneration, EVs may facilitate interactions between photoreceptors and Müller glia cells. In this review, we consider some of the proposed roles for EVs in retinal physiology and discuss current evidence regarding their potential impact on ocular therapies via gene or cell replacement strategies and direct intraocular administration in the diseased eye.
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影响因子：
16
作者：
Flores-Bellver M;Mighty J;Aparicio-Domingo S;Li KV;Shi C;Zhou J;Cobb H;McGrath P;Michelis G;Lenhart P;Bilousova G;Heissel S;Rudy MJ;Coughlan C;Goodspeed AE;Becerra SP;Redenti S;Canto-Soler MV
通讯作者：
Canto-Soler MV
DOI：
10.1002/cne.22047
发表时间：
2009-06-20
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Altick AL;Baryshnikova LM;Vu TQ;von Bartheld CS
通讯作者：
von Bartheld CS
影响因子：
6.9
作者：
Christianson, Helena C.;Belting, Mattias
通讯作者：
Belting, Mattias
影响因子：
4
作者：
Colombo, Marina;Moita, Catarina;Raposo, Graca
通讯作者：
Raposo, Graca
房水中发现的外泌体 miR-29b 介导糖尿病白内障患者的钙信号传导
影响因子：
1.4
作者：
Gao, Chao;Liu, Xin;Luo, Yi
通讯作者：
Luo, Yi