SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum.
SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum.
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SARS-CoV-2感染对血清代谢组学和脂质组学谱的失调。
DOI：
10.1016/j.isci.2020.101645
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发表时间：
2020-10-23
期刊：
影响因子：
5.8
通讯作者：
Millet O
中科院分区：
文献类型：
--
作者：
Bruzzone C;Bizkarguenaga M;Gil-Redondo R;Diercks T;Arana E;García de Vicuña A;Seco M;Bosch A;Palazón A;San Juan I;Laín A;Gil-Martínez J;Bernardo-Seisdedos G;Fernández-Ramos D;Lopitz-Otsoa F;Embade N;Lu S;Mato JM;Millet O
COVID-19是一种全身性感染，对新陈代谢产生重大影响。然而，关于SARS-CoV-2如何影响新陈代谢的信息很少。使用NMR光谱，我们测量了263（训练队列）+ 135（验证队列）有症状的患者在SARS-CoV-2感染PCR检测阳性后住院的代谢组学和脂质组学血清谱。我们亦建立了冠状病毒大流行开始前收集的280人的档案。主成分分析区分两个队列，突出了感染对整体代谢的影响。脂质组学分析揭示了脂蛋白颗粒大小和组成的致病性再分布增加了动脉粥样硬化的风险。反过来，代谢组学分析揭示了异常高水平的酮体（乙酰乙酸，3-羟基丁酸和丙酮）和2-羟基丁酸，肝脏谷胱甘肽合成的读数和氧化应激的标志物。我们的研究结果与SARS-CoV-2感染诱导与血脂异常和氧化应激相关的肝损伤的模型一致。398例COVID-19急性期患者的代谢组学和脂质组学血清谱影响脂蛋白颗粒大小和分布的严重血脂异常中枢代谢失调和酮体蓄积琥珀酸上调类似于癌症中的假缺氧环境人类代谢;病毒学;代谢组学
COVID-19 is a systemic infection that exerts significant impact on the metabolism. Yet, there is little information on how SARS-CoV-2 affects metabolism. Using NMR spectroscopy, we measured the metabolomic and lipidomic serum profile from 263 (training cohort) + 135 (validation cohort) symptomatic patients hospitalized after positive PCR testing for SARS-CoV-2 infection. We also established the profiles of 280 persons collected before the coronavirus pandemic started. Principal-component analysis discriminated both cohorts, highlighting the impact that the infection has on overall metabolism. The lipidomic analysis unraveled a pathogenic redistribution of the lipoprotein particle size and composition to increase the atherosclerotic risk. In turn, metabolomic analysis reveals abnormally high levels of ketone bodies (acetoacetic acid, 3-hydroxybutyric acid, and acetone) and 2-hydroxybutyric acid, a readout of hepatic glutathione synthesis and marker of oxidative stress. Our results are consistent with a model in which SARS-CoV-2 infection induces liver damage associated with dyslipidemia and oxidative stress. Metabolomic and lipidomic serum profile of 398 COVID-19 acute-phase patients Severe dyslipidemia that affects lipoprotein particle size and distribution Central metabolism dysregulation and ketone bodies accumulation Succinic upregulation resembles the pseudohypoxic environment in cancer Human Metabolism; Virology; Metabolomics
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影响因子：
3.7
作者：
Embade N;Mariño Z;Diercks T;Cano A;Lens S;Cabrera D;Navasa M;Falcón-Pérez JM;Caballería J;Castro A;Bosch J;Mato JM;Millet O
通讯作者：
Millet O
影响因子：
2.4
作者：
Filzmoser, Peter;Liebmann, Bettina;Varmuza, Kurt
通讯作者：
Varmuza, Kurt
影响因子：
3.7
作者：
Rist MJ;Roth A;Frommherz L;Weinert CH;Krüger R;Merz B;Bunzel D;Mack C;Egert B;Bub A;Görling B;Tzvetkova P;Luy B;Hoffmann I;Kulling SE;Watzl B
通讯作者：
Watzl B
影响因子：
3.6
作者：
Kluckova K;Tennant DA
通讯作者：
Tennant DA
影响因子：
7.4
作者：
Jimenez, Beatriz;Holmes, Elaine;Nicholson, Jeremy K.
通讯作者：
Nicholson, Jeremy K.