How to Characterize the Function of a Brain Region.

How to Characterize the Function of a Brain Region.
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DOI:
10.1016/j.tics.2018.01.010
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发表时间:
2018-04
影响因子:
19.9
通讯作者:
Eickhoff SB
Eickhoff SB
中科院分区:
心理学1区
文献类型:
--
作者:
Genon S;Reid A;Langner R;Amunts K;Eickhoff SB

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许多大脑区域已经被定义,但每个区域的功能与人类行为的关系仍然缺乏全面的形式化。当前的知识来自各个领域,这些领域具有不同的“功能”概念。我们简要回顾这些领域,并概述了如何利用协会的异质性来揭示任何区域的计算功能。从神经影像学研究中汇总激活数据,使我们能够在一系列实验条件下表征一个区域的功能参与。此外,大样本数据可以揭示脑区特征和生态行为表型之间的协变。将这两种方法结合起来,为确定大脑区域的行为关联开辟了一个新的视角,从而确定其在大规模功能网络中的功能和更广泛的作用。
Many brain regions have been defined, but a comprehensive formalization of each region’s function in relation to human behavior is still lacking. Current knowledge comes from various fields, which have diverse conceptions of ‘functions’. We briefly review these fields and outline how the heterogeneity of associations could be harnessed to disclose the computational function of any region. Aggregating activation data from neuroimaging studies allows us to characterize the functional engagement of a region across a range of experimental conditions. Furthermore, large-sample data can disclose covariation between brain region features and ecological behavioral phenotyping. Combining these two approaches opens a new perspective to determine the behavioral associations of a brain region, and hence its function and broader role within large-scale functional networks.
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