Associations of category fluency clustering performance with in vivo brain pathology in autosomal dominant Alzheimer's disease.
Associations of category fluency clustering performance with in vivo brain pathology in autosomal dominant Alzheimer's disease.
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常染色体显性阿尔茨海默病中类别流畅性聚类表现与体内脑病理学的关联。
DOI：
10.1017/s1355617723000243
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发表时间：
2024
期刊：
影响因子：
--
通讯作者：
Quiroz,YakeelT
中科院分区：
文献类型：
--
作者：
Yucebas,Defne;Fox-Fuller,JoshuaT;BadilloCabrera,Alex;Baena,Ana;PluimMcDowell,Celina;Aduen,Paula;Vila-Castelar,Clara;Bocanegra,Yamile;Tirado,Victoria;Sanchez,JustinS;Cronin-Golomb,Alice;Lopera,Francisco;Quiroz,YakeelT
目的阿尔茨海默病（AD）是众所周知的影响语义访问，这是经常使用类别流畅性（动物）测试进行评估。最近的研究表明，除了整体类别流畅性得分（随着时间的推移产生的单词总数）外，聚类不良可能表明AD相关的认知困难。在这项研究中，我们研究了类别流畅性聚类表现（即，按顺序陈述的话，都包含在一个子类，如家畜）和大脑病理学的个体与常染色体显性阿尔茨海默氏病（ADAD）MethodsA共29个非痴呆携带者的早老素1 E280 A ADAD突变和32 noncarrier家庭成员完成了类别流畅性测试（动物）和简易精神状态检查（MMSE）。参与者还接受了正电子发射断层扫描（PET）扫描，以评估新皮质中的体内淀粉样蛋白β和内侧颞叶区域中的tau蛋白。携带者和非携带者之间的认知测试的差异进行了评估与Mann-Whitney测试;认知测试性能和大脑病理学之间的关联进行了评估与斯皮尔曼correlations.ResultsAnimal流畅性得分没有差异之间的载体和非载体。载体，但是，表现出较强的关联动物流畅性聚类和体内AD脑病理（新皮质淀粉样蛋白和内嗅tau蛋白）相对noncarriers.ConclusionThis研究表明，使用类别流畅性聚类，但不是总得分，与AD的病理生理在临床前和疾病的早期阶段。
ObjectivesAlzheimer’s disease (AD) is known to impact semantic access, which is frequently evaluated using the Category Fluency (Animals) test. Recent studies have suggested that in addition to overall category fluency scores (total number of words produced over time), poor clustering could signal AD-related cognitive difficulties. In this study, we examined the association between category fluency clustering performance (i.e., stating words sequentially that are all contained within a subcategory, such as domestic animals) and brain pathology in individuals with autosomal dominant Alzheimer’s disease (ADAD).MethodsA total of 29 non-demented carriers of the Presenilin1 E280A ADAD mutation and 32 noncarrier family members completed the category fluency test (Animals) and the Mini-Mental State Examination (MMSE). The participants also underwent positron emission tomography (PET) scans to evaluate in vivo amyloid-beta in the neocortex and tau in medial temporal lobe regions. Differences between carriers and noncarriers on cognitive tests were assessed with Mann-Whitney tests; associations between cognitive test performance and brain pathology were assessed with Spearman correlations.ResultsAnimal fluency scores did not differ between carriers and noncarriers. Carriers, however, showed a stronger association between animal fluency clustering and in vivo AD brain pathology (neocortical amyloid and entorhinal tau) relative to noncarriers.ConclusionThis study indicates that using category fluency clustering, but not total score, is related to AD pathophysiology in the preclinical and early stages of the disease.
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